Smart R G, Mann R E
Addiction Research Foundation, Toronto, Ontario, Canada.
Br J Addict. 1990 Oct;85(10):1291-8. doi: 10.1111/j.1360-0443.1990.tb01605.x.
Recent reductions in liver cirrhosis morbidity and mortality rates have been noted in many Western countries. We have previously observed that these declines are associated with increases in treatment for alcohol abuse over regions of Ontario, and increases in Alcoholics Anonymous (AA) membership over American states. One important question is whether the potential impact of treatment and AA membership increases could be large enough to have an impact on population cirrhosis rates. We explore this issue using estimates of the effects of treatment and AA membership, and of the likelihood of alcohol abusers developing cirrhosis, derived from the research literature. The results suggest that increases in treatment and AA membership could indeed have made important contributions to declines in cirrhosis mortality and morbidity in Ontario (1975-82) and the USA (1979-82).
许多西方国家近期已注意到肝硬化发病率和死亡率有所下降。我们之前观察到，这些下降与安大略省各地区酗酒治疗的增加以及美国各州戒酒互助会（AA）会员人数的增加有关。一个重要问题是，治疗和戒酒互助会会员人数增加的潜在影响是否可能大到足以对总体肝硬化发病率产生影响。我们利用从研究文献中得出的治疗和戒酒互助会会员人数的影响估计值，以及酗酒者患肝硬化的可能性估计值来探讨这个问题。结果表明，治疗和戒酒互助会会员人数的增加确实可能对安大略省（1975 - 1982年）和美国（1979 - 1982年）肝硬化死亡率和发病率的下降做出了重要贡献。
