Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Dermatitis. 2012 Mar-Apr;23(2):61-70. doi: 10.1097/DER.0b013e31824a625e.
Patients with a sore or burning mouth associated with clinically normal oral mucosa present a difficult diagnostic challenge.
The objective of this study was to assess the value of patch testing in patients with burning mouth syndrome.
We retrospectively reviewed the results of patch testing to an oral series in patients with burning mouth syndrome seen at Mayo Clinic, Rochester, Minnesota, between January 2000 and April 2006.
Of 195 consecutive patients with a burning or sore mouth, 75 had patch testing to an oral series, and 28 of these patients (37.3%) had allergic patch test reactions. The most common allergens were nickel sulfate hexahydrate 2.5%, balsam of Peru, and gold sodium thiosulfate 0.5%. On follow-up, 15 patients reported improvement, 4 removed or avoided the offending dental metal, and 6 avoided the dietary allergen. Thirteen patients did not improve; 6 avoided identified allergens, but without improvement; 1 removed dental metals without symptom change; and 5 avoided test-positive dietary allergens but without improvement. The remaining 7 nonresponders had nonrelevant patch test results or did not avoid allergens.
Patch testing can identify patients who may be allergic to dental metals or dietary additives and who may benefit from removal or avoidance of these.
伴有临床正常口腔黏膜的口腔疼痛或灼热感的患者提出了具有挑战性的诊断难题。
本研究旨在评估斑贴试验在灼口综合征患者中的价值。
我们回顾性分析了 2000 年 1 月至 2006 年 4 月期间在明尼苏达州罗切斯特市梅奥诊所就诊的灼口综合征患者的口腔系列斑贴试验结果。
在 195 例口腔疼痛或灼热的连续患者中，75 例接受了口腔系列斑贴试验，其中 28 例（37.3%）有过敏斑贴试验反应。最常见的变应原是六水合硫酸镍 2.5%、秘鲁香脂和金钠硫代硫酸 0.5%。随访时，15 例患者报告症状改善，4 例患者去除或避免了引起症状的牙科金属，6 例患者避免了饮食变应原。13 例患者未改善；6 例避免了已识别的变应原，但症状无改善；1 例去除了牙科金属，但症状无变化；5 例避免了阳性斑贴试验变应原，但症状无改善。其余 7 例无反应者的斑贴试验结果不相关或未避免变应原。
斑贴试验可识别可能对牙科金属或饮食添加剂过敏并可能从中受益的患者，这些患者可通过去除或避免这些物质获益。
