Gomez-Casado Cristina, Sanchez-Solares Javier, Izquierdo Elena, Díaz-Perales Araceli, Barber Domingo, Escribese María M
Institute of Applied Molecular Medicine, Department of Basic Medical Sciences, Faculty of Medicine, San Pablo CEU University, 28003 Madrid, Spain.
Center of Plant Biotechnology and Genomics, Technical University of Madrid, 28040 Madrid, Spain.
Foods. 2021 Apr 28;10(5):970. doi: 10.3390/foods10050970.
Most prevalent food allergies during early childhood are caused by foods with a high allergenic protein content, such as milk, egg, nuts, or fish. In older subjects, some respiratory allergies progressively lead to food-induced allergic reactions, which can be severe, such as urticaria or asthma. Oral mucosa remodeling has been recently proven to be a feature of severe allergic phenotypes and autoimmune diseases. This remodeling process includes epithelial barrier disruption and the release of inflammatory signals. Although little is known about the immune processes taking place in the oral mucosa, there are a few reports describing the oral mucosa-associated immune system. In this review, we will provide an overview of the recent knowledge about the role of the oral mucosa in food-induced allergic reactions, as well as in severe respiratory allergies or food-induced autoimmune diseases, such as celiac disease.
幼儿期最常见的食物过敏是由高致敏蛋白含量的食物引起的，如牛奶、鸡蛋、坚果或鱼类。在年龄较大的人群中，一些呼吸道过敏会逐渐引发食物诱导的过敏反应，这些反应可能很严重，如荨麻疹或哮喘。最近已证实口腔黏膜重塑是严重过敏表型和自身免疫性疾病的一个特征。这个重塑过程包括上皮屏障破坏和炎症信号的释放。尽管人们对口腔黏膜中发生的免疫过程知之甚少，但有一些报告描述了口腔黏膜相关免疫系统。在这篇综述中，我们将概述关于口腔黏膜在食物诱导的过敏反应以及严重呼吸道过敏或食物诱导的自身免疫性疾病（如乳糜泻）中所起作用的最新知识。
