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Infliximab treatment of pancreatitis complicating acute kawasaki disease.英夫利昔单抗治疗并发急性川崎病的胰腺炎。
Pediatr Infect Dis J. 2012 Oct;31(10):1087-9. doi: 10.1097/INF.0b013e31826108c2.
2
Primary treatment of incomplete Kawasaki disease with infliximab and methylprednisolone in a patient with a contraindication to intravenous immune globulin.英夫利昔单抗和甲泼尼龙治疗静脉用免疫球蛋白禁忌的不完全川崎病患儿。
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Infliximab treatment for pediatric refractory Kawasaki disease.英夫利昔单抗治疗儿童难治性川崎病。
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Infliximab for intensification of primary therapy for Kawasaki disease: a phase 3 randomised, double-blind, placebo-controlled trial.英夫利昔单抗强化川崎病一线治疗：一项 3 期随机、双盲、安慰剂对照试验。
Lancet. 2014 May 17;383(9930):1731-8. doi: 10.1016/S0140-6736(13)62298-9. Epub 2014 Feb 24.
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Role of intravenous immunoglobulin in the treatment of Kawasaki disease.静脉注射免疫球蛋白在川崎病治疗中的作用。
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Should infliximab be used as an adjuvant to IVIG in the treatment of children with Kawasaki disease who are at high risk for resistance to conventional therapy?英夫利昔单抗是否应用于对传统治疗耐药风险高的川崎病患儿，作为静脉注射免疫球蛋白的辅助治疗？
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Infliximab treatment for refractory Kawasaki disease with coronary artery aneurysm.英夫利昔单抗治疗难治性川崎病伴冠状动脉瘤。
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[Intravenous immunoglobulin-resistant Kawasaki disease with hemophagocytosis].伴有噬血细胞现象的静脉注射免疫球蛋白抵抗型川崎病
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[Refractory Kawasaki disease with coronary aneurysms treated with infliximab].[英夫利昔单抗治疗伴有冠状动脉瘤的难治性川崎病]
An Pediatr (Barc). 2010 Nov;73(5):268-71. doi: 10.1016/j.anpedi.2010.06.006. Epub 2010 Aug 3.

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Intravenous Immunoglobulin Infusion Reactions in Kawasaki Disease Patients Who Undergo Sedation.接受镇静的川崎病患者静脉注射免疫球蛋白的反应
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Intravenous Immunoglobulin Gamma (IVIG) versus IVIG Plus Infliximab in Young Children with Kawasaki Disease.静脉注射免疫球蛋白γ（IVIG）与 IVIG 联合英夫利昔单抗治疗川崎病患儿的比较
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Typical Kawasaki Disease Presenting With Pancreatitis and Bilateral Parotid Gland Involvement: A Case Report and Literature Review.以胰腺炎和双侧腮腺受累为表现的典型川崎病：一例报告及文献复习
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Peripancreatic fat necrosis worsens acute pancreatitis independent of pancreatic necrosis via unsaturated fatty acids increased in human pancreatic necrosis collections.胰腺周围脂肪坏死通过人胰腺坏死标本中增加的不饱和脂肪酸，在不依赖胰腺坏死的情况下加重急性胰腺炎。
Gut. 2016 Jan;65(1):100-11. doi: 10.1136/gutjnl-2014-308043. Epub 2014 Dec 10.
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Immunomodulatory therapies for acute pancreatitis.急性胰腺炎的免疫调节疗法。
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Role of pancreatic fat in the outcomes of pancreatitis.胰腺脂肪在胰腺炎预后中的作用。
Pancreatology. 2014 Sep-Oct;14(5):403-8. doi: 10.1016/j.pan.2014.06.004. Epub 2014 Jul 1.

本文引用的文献

1
Associated symptoms in the ten days before diagnosis of Kawasaki disease.川崎病诊断前十天的相关症状。
J Pediatr. 2009 Apr;154(4):592-595.e2. doi: 10.1016/j.jpeds.2008.10.006. Epub 2008 Nov 28.
2
Infliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease.英夫利昔单抗治疗对静脉注射免疫球蛋白耐药的川崎病
J Pediatr. 2008 Dec;153(6):833-8. doi: 10.1016/j.jpeds.2008.06.011. Epub 2008 Jul 30.
3
Resistance to intravenous immunoglobulin in children with Kawasaki disease.川崎病患儿对静脉注射免疫球蛋白的耐药性。
J Pediatr. 2008 Jul;153(1):117-21. doi: 10.1016/j.jpeds.2007.12.021. Epub 2008 Mar 4.
4
Infliximab: a new therapeutic agent in acute pancreatitis?英夫利昔单抗：急性胰腺炎的一种新型治疗药物？
Pancreas. 2004 Jan;28(1):e1-8. doi: 10.1097/00006676-200401000-00020.
5
CD8 T lymphocytes and macrophages infiltrate coronary artery aneurysms in acute Kawasaki disease.CD8 T淋巴细胞和巨噬细胞浸润急性川崎病患者的冠状动脉瘤。
J Infect Dis. 2001 Oct 1;184(7):940-3. doi: 10.1086/323155. Epub 2001 Aug 22.
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Re: Triantafillidis et al.--Acute idiopathic pancreatitis complicating active Crohn's disease: favorable response to infliximab treatment.
Am J Gastroenterol. 2001 Aug;96(8):2510-1. doi: 10.1111/j.1572-0241.2001.04070.x.
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Acute idiopathic pancreatitis complicating active Crohn's disease: favorable response to infliximab treatment.
Am J Gastroenterol. 2000 Nov;95(11):3334-6. doi: 10.1111/j.1572-0241.2000.03332.x.
8
Timing of tumor necrosis factor antagonism is critical in determining outcome in murine lethal acute pancreatitis.肿瘤坏死因子拮抗作用的时机对于确定小鼠致死性急性胰腺炎的结局至关重要。
Surgery. 1996 Sep;120(3):515-21. doi: 10.1016/s0039-6060(96)80072-9.
9
Inhibition of TNF alpha improves survival in an experimental model of acute pancreatitis.肿瘤坏死因子α的抑制作用可提高急性胰腺炎实验模型的存活率。
Am Surg. 1996 Jan;62(1):8-13.
10
Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression.急性胰腺炎可诱导胰腺内肿瘤坏死因子基因表达。
Arch Surg. 1995 Sep;130(9):966-70. doi: 10.1001/archsurg.1995.01430090052018.

英夫利昔单抗治疗并发急性川崎病的胰腺炎。

Infliximab treatment of pancreatitis complicating acute kawasaki disease.

机构信息

Department of Pediatrics, 9500 Gilman Dr, Mail Code 0831 La Jolla, CA 92093-0831, USA.

出版信息

Pediatr Infect Dis J. 2012 Oct;31(10):1087-9. doi: 10.1097/INF.0b013e31826108c2.

DOI:10.1097/INF.0b013e31826108c2
PMID:22653489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3444621/
Abstract

Kawasaki disease can be associated with gastrointestinal complications, including pancreatitis. We describe a child in whom infliximab infusion for intravenous immunoglobulin-resistant Kawasaki disease coincided with marked clinical improvement of the patient's acute pancreatitis.

摘要

川崎病可伴有胃肠道并发症，包括胰腺炎。我们描述了一例患儿，其因静脉注射免疫球蛋白耐药性川崎病而输注英夫利昔单抗，同时患者的急性胰腺炎也明显改善。