Department of Internal Medicine, University of North Texas Health Sciences Center, Fort Worth, TX, USA.
Int J Geriatr Psychiatry. 2013 Apr;28(4):377-82. doi: 10.1002/gps.3835. Epub 2012 May 31.
Depression is the most commonly reported psychiatric symptom in patients with mild cognitive impairment (MCI). However, more research is needed examining the impact of depression on cognitive functioning in MCI patients. The purpose of this study was to examine differences in cognitive functioning in a sample of community- based, depressed, and non-depressed MCI patients.
One hundred and five participants with MCI were included in this study. Participants were recruited from Project FRONTIER, a study of rural health. Depression was assessed via the Geriatric Depression Scale (GDS-30), and cognition was measured using the Repeatable Battery for the Assessment of Neuropsychological Status.
The results indicated that depressed MCI participants performed significantly worse than their non-depressed counterparts on several cognitive measures. MCI participants with depression scored significantly lower on immediate memory (t = 3.4, p < 0.01) and delayed memory (t = 2.8, p < 0.01) indices than their non-depressed counterparts.
The results of this study indicated that MCI participants with depression experienced greater deficits in cognitive functioning than their non-depressed counterparts. Depressed MCI participants exhibited greater deficits in both immediate and delayed memory. Thus, identifying and treating depression in individuals with MCI may improve memory and cognitive functioning.
抑郁是轻度认知障碍（MCI）患者中最常报告的精神症状。然而，需要更多的研究来检查抑郁对 MCI 患者认知功能的影响。本研究的目的是检查社区为基础的抑郁和非抑郁 MCI 患者样本中认知功能的差异。
本研究纳入了 105 名 MCI 患者。参与者是从 FRONTIER 项目中招募的，这是一项农村健康研究。抑郁通过老年抑郁量表（GDS-30）进行评估，认知通过重复性神经心理状态评估量表进行测量。
结果表明，抑郁的 MCI 参与者在几项认知测试中的表现明显逊于非抑郁的参与者。与非抑郁的参与者相比，患有抑郁症的 MCI 参与者在即时记忆（t=3.4，p<0.01）和延迟记忆（t=2.8，p<0.01）指标上的得分明显较低。
本研究的结果表明，患有抑郁症的 MCI 参与者在认知功能方面的表现比非抑郁的参与者更差。患有抑郁症的 MCI 参与者在即时记忆和延迟记忆方面都表现出更大的缺陷。因此，在 MCI 患者中识别和治疗抑郁症可能会改善记忆和认知功能。
