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氟康唑敏感性关键区突变和细胞壁几丁质增加导致白念珠菌血流分离株对卡泊芬净短暂暴露后出现棘白菌素类耐药

Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin.

机构信息

John Lynch Renal Unit & Department of Microbiology, University Hospital Crosshouse, Kilmarnock, UK.

School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.

出版信息

J Med Microbiol. 2012 Sep;61(Pt 9):1330-1334. doi: 10.1099/jmm.0.045047-0. Epub 2012 May 31.

DOI:10.1099/jmm.0.045047-0
PMID:22653922
Abstract

Echinocandins are first-line agents for treating severe invasive candidiasis. Glucan synthase gene (FKS1) mutations lead to echinocandin resistance but the role of enhanced chitin expression is not well recognized in clinical isolates. We report a case of bloodstream Candida albicans infection with both Fks1 hotspot mutation and elevated cell wall chitin.

摘要

棘白菌素类药物是治疗严重侵袭性念珠菌病的一线药物。葡聚糖合酶基因（FKS1）突变导致棘白菌素类药物耐药，但临床分离株中增强的壳聚糖表达的作用尚未得到很好的认识。我们报告了一例血流感染的白色念珠菌感染病例，同时存在 Fks1 热点突变和细胞壁壳聚糖升高。

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Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin.氟康唑敏感性关键区突变和细胞壁几丁质增加导致白念珠菌血流分离株对卡泊芬净短暂暴露后出现棘白菌素类耐药
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