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褪黑素治疗对糖尿病性眼和脑氧化应激及细胞凋亡的影响。

The effects of the melatonin treatment on the oxidative stress and apoptosis in diabetic eye and brain.

作者信息

Gürpınar Tuğba, Ekerbiçer Nuran, Uysal Nazan, Barut Turgay, Tarakçı Figen, Tuglu M Ibrahim

机构信息

Department of Pharmacology, Faculty of Medicine, Celal Bayar University, 45030 Manisa, Turkey.

出版信息

ScientificWorldJournal. 2012;2012:498489. doi: 10.1100/2012/498489. Epub 2012 May 1.

DOI:10.1100/2012/498489
PMID:22654617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3361279/
Abstract

Oxidative stress plays an important role in the development of complications in diabetes mellitus. Antioxidant therapy has been thought to decrease oxidative stress. The objective of the present study was to explore the effects of melatonin (MLT) on oxidative stress in diabetic rat eye and brain tissue by using immunohistochemical methods. Diabetes was induced by streptozotocin, (STZ, 55 mg/kg/i.p) in adult rats. MLT was given 10 mg/kg/i.p once a day for 2 weeks beginning from the sixth week. Six weeks later, rats were divided into three groups: control (CR), STZ-induced diabetic (STZ), and STZ-induced diabetic group received melatonin (STZ+MLT). Although no significant difference was observed with respect to antioxidant status, NOS activity tended to be higher in the untreated diabetic rats than in the treated rats. It was observed that MLT treatment improved the histopathological changes including apoptosis and oxidative stress in brain and eye in diabetic rat.

摘要

氧化应激在糖尿病并发症的发生发展中起重要作用。抗氧化治疗被认为可降低氧化应激。本研究的目的是通过免疫组化方法探讨褪黑素（MLT）对糖尿病大鼠眼和脑组织氧化应激的影响。成年大鼠腹腔注射链脲佐菌素（STZ，55mg/kg）诱导糖尿病。从第六周开始，每天腹腔注射10mg/kg的MLT，持续2周。六周后，将大鼠分为三组：对照组（CR）、STZ诱导的糖尿病组（STZ）和接受褪黑素的STZ诱导糖尿病组（STZ+MLT）。尽管在抗氧化状态方面未观察到显著差异，但未治疗的糖尿病大鼠的一氧化氮合酶（NOS）活性往往高于治疗组大鼠。观察到MLT治疗改善了糖尿病大鼠脑和眼中包括细胞凋亡和氧化应激在内的组织病理学变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edb/3361279/8bf454a6be0d/TSWJ2012-498489.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edb/3361279/c17d684e485d/TSWJ2012-498489.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edb/3361279/cc6dbd7ba5a0/TSWJ2012-498489.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edb/3361279/83968bcb3cdf/TSWJ2012-498489.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edb/3361279/8bf454a6be0d/TSWJ2012-498489.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edb/3361279/c17d684e485d/TSWJ2012-498489.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edb/3361279/cc6dbd7ba5a0/TSWJ2012-498489.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edb/3361279/83968bcb3cdf/TSWJ2012-498489.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8edb/3361279/8bf454a6be0d/TSWJ2012-498489.004.jpg

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