Walter and Eliza Hall Institute of Medical Research Parkville, VIC, Australia.
Front Endocrinol (Lausanne). 2011 Nov 22;2:76. doi: 10.3389/fendo.2011.00076. eCollection 2011.
Ever since the discovery of insulin and its role in the regulation of glucose uptake and utilization, there has been great interest in insulin, its structure and the way in which it interacts with its receptor and effects signal transduction. As the 90th anniversary of the discovery of insulin approaches, it is timely to provide an overview of the landmark discoveries relating to the structure and function of this remarkable molecule and its receptor.
自从胰岛素的发现及其在调节葡萄糖摄取和利用中的作用被揭示以来，人们对胰岛素、其结构以及它与受体相互作用并影响信号转导的方式一直非常感兴趣。随着胰岛素发现 90 周年的临近，现在及时提供有关该非凡分子及其受体的结构和功能的里程碑式发现的概述是适时的。
