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中危前列腺癌患者的放射治疗。

Radiation treatment for patients with intermediate-risk prostate cancer.

机构信息

Lieutenant Commander, 4501 X st, Radiation Oncology, Sacramento, CA 95817, USA.

出版信息

Ther Adv Urol. 2012 Jun;4(3):113-24. doi: 10.1177/1756287212442977.

DOI:10.1177/1756287212442977
PMID:22654963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3361750/
Abstract

Around 70% of men presenting with prostate cancer will have organ-confined disease, with the majority presenting with low- or intermediate-risk prostate cancer. This article reviews the evidence supporting the current standard of care in radiation oncology for the evaluation and management of men with intermediate-risk prostate cancer. Dose escalation, hormonal therapy, combined modality therapy, and modern techniques for the delivery of radiation therapy are reviewed.

摘要

约 70%的前列腺癌患者为局限性前列腺癌，其中大多数为低危或中危前列腺癌。本文回顾了支持当前放射肿瘤学中对中危前列腺癌患者评估和管理的标准治疗方法的证据。对提高剂量、激素治疗、联合治疗模式以及放射治疗的现代技术进行了回顾。

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Radiation treatment for patients with intermediate-risk prostate cancer.中危前列腺癌患者的放射治疗。
Ther Adv Urol. 2012 Jun;4(3):113-24. doi: 10.1177/1756287212442977.
2
American Brachytherapy Society Task Group Report: Combination of brachytherapy and external beam radiation for high-risk prostate cancer.美国近距离放射治疗学会任务组报告：近距离放射治疗与外照射放疗联合用于高危前列腺癌
Brachytherapy. 2017 Jan-Feb;16(1):1-12. doi: 10.1016/j.brachy.2016.09.006. Epub 2016 Oct 19.
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Management of localised prostate cancer: watchful waiting, surgery or radiation therapy, depending on the natural course, which is often relatively slow.局限性前列腺癌的治疗：根据其自然病程（通常进展相对缓慢），可选择观察等待、手术或放射治疗。
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Excellent results from high dose rate brachytherapy and external beam for prostate cancer are not improved by androgen deprivation.高剂量率近距离放射疗法和外照射治疗前列腺癌的卓越疗效不会因雄激素剥夺而得到改善。
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Outcomes and toxicities in patients with intermediate-risk prostate cancer treated with brachytherapy alone or brachytherapy and supplemental external beam radiation therapy.单独接受近距离放射治疗或近距离放射治疗联合补充外部束放射治疗的中危前列腺癌患者的结局和毒性。
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A combined single high-dose rate brachytherapy boost with hypofractionated external beam radiotherapy results in a high rate of biochemical disease free survival in localised intermediate and high risk prostate cancer patients.高剂量率近距离放疗联合低分割外照射放疗可使局限性中高危前列腺癌患者获得较高的无生化复发生存率。
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Intravesical Therapies for Radiation Cystitis.放射性膀胱炎的膀胱内治疗
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本文引用的文献

1
Phase I dose-escalation study of stereotactic body radiation therapy for low- and intermediate-risk prostate cancer.立体定向体部放射治疗低危和中危前列腺癌的 I 期剂量递增研究。
J Clin Oncol. 2011 May 20;29(15):2020-6. doi: 10.1200/JCO.2010.31.4377. Epub 2011 Apr 4.
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Short-term neoadjuvant androgen deprivation and radiotherapy for locally advanced prostate cancer: 10-year data from the TROG 96.01 randomised trial.局部晚期前列腺癌的短期新辅助雄激素剥夺和放疗：来自 TROG 96.01 随机试验的 10 年数据。
Lancet Oncol. 2011 May;12(5):451-9. doi: 10.1016/S1470-2045(11)70063-8.
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MRI of the prostate: clinical relevance and emerging applications.前列腺 MRI：临床相关性及新兴应用
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Dose escalation improves cancer-related events at 10 years for intermediate- and high-risk prostate cancer patients treated with hypofractionated high-dose-rate boost and external beam radiotherapy.对于接受低分割高剂量率推量和外部束放射治疗的中高危前列腺癌患者，剂量递增可改善 10 年时的癌症相关事件。
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Analysis of second malignancies after modern radiotherapy versus prostatectomy for localized prostate cancer.局部前列腺癌采用现代放疗与前列腺切除术治疗后的第二恶性肿瘤分析。
Radiother Oncol. 2011 Jan;98(1):81-6. doi: 10.1016/j.radonc.2010.09.012. Epub 2010 Oct 14.
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External irradiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study.高危转移性前列腺癌的外照射放疗或联合长期雄激素抑制治疗：EORTC 随机研究的 10 年结果。
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Cancer statistics, 2010.癌症统计数据，2010 年。
CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300. doi: 10.3322/caac.20073. Epub 2010 Jul 7.
8
CyberKnife stereotactic radiotherapy as monotherapy for low- to intermediate-stage prostate cancer: early experience, feasibility, and tolerance.CyberKnife 立体定向放疗作为低至中危前列腺癌的单一疗法：早期经验、可行性和耐受性。
J Endourol. 2010 May;24(5):865-9. doi: 10.1089/end.2009.0438.
9
Stereotactic body radiotherapy for primary management of early-stage, low- to intermediate-risk prostate cancer: report of the American Society for Therapeutic Radiology and Oncology Emerging Technology Committee.立体定向体部放射治疗用于早期低至中度风险前列腺癌的初始治疗：美国放射肿瘤学会新兴技术委员会报告
Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1297-304. doi: 10.1016/j.ijrobp.2009.09.078.
10
Randomized trial comparing conventional-dose with high-dose conformal radiation therapy in early-stage adenocarcinoma of the prostate: long-term results from proton radiation oncology group/american college of radiology 95-09.随机对照试验比较常规剂量与高剂量适形放疗在早期前列腺腺癌：来自质子放射肿瘤学组/美国放射学院 95-09 的长期结果。
J Clin Oncol. 2010 Mar 1;28(7):1106-11. doi: 10.1200/JCO.2009.25.8475. Epub 2010 Feb 1.