Departamento de Génetica del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, UNAM, Cuernavaca, Morelos 62210, Mexico.
Curr Opin Virol. 2012 Aug;2(4):389-98. doi: 10.1016/j.coviro.2012.05.001. Epub 2012 May 31.
As obligate parasites, viruses depend on the synthetic machinery of the cell to translate their proteins and on the cell's energy and building blocks to replicate their genomes. Cells respond to virus invasions by eliciting diverse responses to eliminate the incoming parasitic agents. In turn, to establish a successful infection, viruses have developed different strategies to take over the cellular metabolic machinery and to cope with the defense mechanisms of the cell. The characterization of this battle has allowed the discovery of the different elements that viruses and cells have developed in the attempt to overcome the enemy. Here some of the strategies used by rotaviruses to hijack the protein synthesis apparatus of the cell to ensure the translation of their mRNAs, and to deal with the cellular stress and antiviral responses will be reviewed.
作为专性寄生生物，病毒依赖于细胞的合成机制来翻译其蛋白质，并依赖于细胞的能量和构建块来复制其基因组。细胞通过引发多种反应来消除入侵的寄生虫来应对病毒入侵。反过来，为了建立成功的感染，病毒已经开发了不同的策略来接管细胞的新陈代谢机制，并应对细胞的防御机制。对这场战斗的描述使得人们发现了病毒和细胞为了克服对方而开发的不同元素。本文将综述轮状病毒劫持细胞蛋白质合成装置以确保其 mRNA 翻译的一些策略，以及应对细胞应激和抗病毒反应的策略。
