体重变化与脂蛋白颗粒浓度和粒径：一项具有 6.5 年随访的队列研究。

Weight change and lipoprotein particle concentration and particle size: a cohort study with 6.5-year follow-up.

机构信息

Institute of Public Health and Clinical Nutrition, Primary Health Care, School of Medicine, University of Eastern Finland, Kuopio, Finland.

出版信息

Atherosclerosis. 2012 Jul;223(1):239-43. doi: 10.1016/j.atherosclerosis.2012.05.005. Epub 2012 May 15.

DOI:10.1016/j.atherosclerosis.2012.05.005

PMID:22658258

Abstract

OBJECTIVE

Obesity and overweight are related to unfavourable lipoprotein subclass profiles. Here we studied the relation between weight change and lipoprotein particle concentrations and sizes in a general population cohort in a longitudinal setting.

METHODS

The cohort included 683 adults with a 6.5-year follow-up. Lipoprotein particle subclasses and mean particle sizes of VLDL, LDL, and HDL were measured by nuclear magnetic resonance spectroscopy.

RESULTS

During the follow-up period, a weight loss of at least 5% was associated with decreased particle concentrations of all apoB-containing subclasses and increased concentrations of large HDL particles. Coherently, weight gain (≥5%) was associated with increases in all apoB-containing subclasses and decreases in total and medium HDL particle concentrations. The relatively largest increase occurred for large HDL particle concentration (24.1%, 95% CI 15.8-32.5) in weight loss and for large VLDL particle concentration (33.0%, 19.6-46.4) in weight gain. Weight change correlated positively with changes in apoB-containing lipoprotein particle concentrations and also with the change in average VLDL particle size. Negative correlations were found between weight change and the change in average LDL (r = -0.10) and HDL (r = -0.32) particle size, but not between weight change and total HDL particle concentration.

CONCLUSION

Moderate weight loss is related to favourable and weight gain to unfavourable changes in lipoprotein subclass profiles. These population level findings underline the importance of weight control as a modifier of cardiovascular risk factors.

摘要

目的

肥胖和超重与不利的脂蛋白亚类谱有关。本研究在纵向研究中，研究了一般人群中体重变化与脂蛋白颗粒浓度和大小的关系。

方法

该队列包括 683 名成年人，随访时间为 6.5 年。采用核磁共振光谱法测定 VLDL、LDL 和 HDL 的脂蛋白颗粒亚类和平均颗粒大小。

结果

在随访期间，体重减轻至少 5%与所有载 apoB 的亚类颗粒浓度降低和大 HDL 颗粒浓度增加有关。一致地，体重增加（≥5%）与所有载 apoB 的亚类颗粒浓度增加和总 HDL 和中 HDL 颗粒浓度降低有关。体重减轻时大 HDL 颗粒浓度增加最大（24.1%，95%CI 15.8-32.5），体重增加时大 VLDL 颗粒浓度增加最大（33.0%，19.6-46.4）。体重变化与载 apoB 的脂蛋白颗粒浓度变化呈正相关，与 VLDL 颗粒平均大小的变化也呈正相关。体重变化与 LDL（r=-0.10）和 HDL（r=-0.32）颗粒平均大小的变化呈负相关，但与总 HDL 颗粒浓度的变化无相关性。