Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA.
Contemp Clin Trials. 2012 Sep;33(5):1056-64. doi: 10.1016/j.cct.2012.05.008. Epub 2012 May 29.
Cognitive-behavioral therapy (CBT) is currently the "gold standard" for treatment of bulimia nervosa (BN), and is effective for approximately 40-60% of individuals receiving treatment; however, the majority of individuals in need of care do not have access to CBT. New strategies for service delivery of CBT and for maximizing maintenance of treatment benefits are critical for improving our ability to treat BN. This clinical trial is comparing an Internet-based version of CBT (CBT4BN) in which group intervention is conducted via therapeutic chat group with traditional group CBT (CBTF2F) for BN conducted via face-to-face therapy group. The purpose of the trial is to determine whether manualized CBT delivered via the Internet is not inferior to the gold standard of manualized group CBT. In this two-site randomized controlled trial, powered for non-inferiority analyses, 180 individuals with BN are being randomized to either CBT4BN or CBTF2F. We hypothesize that CBT4BN will not be inferior to CBTF2F and that participants will value the convenience of an online intervention. If not inferior, CBT4BN may be a cost-effective approach to service delivery for individuals requiring treatment for BN.
认知行为疗法(CBT)目前是治疗神经性贪食症(BN)的“金标准”,对于接受治疗的大约 40-60%的个体有效;然而,大多数需要护理的人无法获得 CBT。为 CBT 的服务提供新策略和最大限度地保持治疗效果对于提高我们治疗 BN 的能力至关重要。这项临床试验正在比较一种基于互联网的 CBT 版本(CBT4BN),其中通过治疗性聊天小组进行小组干预,而传统的面对面治疗小组进行的 BN 团体 CBT(CBTF2F)。该试验的目的是确定通过互联网提供的规范化 CBT 是否不劣于规范化团体 CBT 的黄金标准。在这项双站点随机对照试验中,为非劣效性分析提供了动力,180 名 BN 患者被随机分配到 CBT4BN 或 CBTF2F 组。我们假设 CBT4BN 不会劣于 CBTF2F,并且参与者将重视在线干预的便利性。如果不劣于 CBTF2F,CBT4BN 可能是为需要 BN 治疗的个体提供服务的一种具有成本效益的方法。