Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Exp Parasitol. 2012 Aug;131(4):448-51. doi: 10.1016/j.exppara.2012.04.016. Epub 2012 May 29.
Studies have shown that symptomatic infection by Giardia lamblia causes acute or chronic diarrhea, dehydration, abdominal pain and malabsorption, leading to undernutrition and weight loss. The aim of the present study was to evaluate the effects of giardiasis and its combination with a low-protein diet on the intestinal absorption of glucose and electrolytes in gerbils. The intestinal absorption of glucose, sodium and potassium was investigated in male gerbils weighing 46-64 g (n≥5). A Tyrode solution containing twice the glucose, sodium and potassium concentration (pH 7.4) was infused through the intestinal loops for 40 min. Glucose absorption was not significantly affected by diet and infection. However, there was a significant increase in sodium absorption in the Giardia-infected group (57.2±6.1, p<0.05) in comparison to the control, low-protein diet and low-protein diet+Giardia-infected groups (8.9±6.5, 2.8±11.1 and 0.8±7.9, respectively; p<0.05). Moreover, potassium was absorbed in the Giardia-infected group (0.45±0.30), while the other groups exhibited potassium secretion. A low-protein diet and Giardia infection had no influence over glucose absorption. However, Giardia infection increased sodium and potassium uptake, suggesting a compensatory mechanism for maintaining homeostasis after likely hypernatremia and hypokalemia caused by the diarrhea that accompanies giardiasis.
研究表明，蓝氏贾第鞭毛虫引起的症状性感染会导致急性或慢性腹泻、脱水、腹痛和吸收不良，从而导致营养不良和体重减轻。本研究旨在评估贾第虫病及其与低蛋白饮食的组合对沙鼠肠道吸收葡萄糖和电解质的影响。研究人员对体重为 46-64g 的雄性沙鼠（n≥5）进行了肠内葡萄糖、钠和钾的吸收研究。用 Tyrode 溶液（葡萄糖、钠和钾浓度为正常浓度的两倍，pH 值为 7.4）通过肠袢输注 40 分钟。饮食和感染对葡萄糖吸收没有显著影响。然而，与对照组、低蛋白饮食组和低蛋白饮食+贾第虫感染组相比，感染组的钠吸收显著增加（57.2±6.1，p<0.05）（分别为 8.9±6.5、2.8±11.1 和 0.8±7.9；p<0.05）。此外，感染组的钾被吸收（0.45±0.30），而其他组则表现为钾分泌。低蛋白饮食和贾第虫感染对葡萄糖吸收没有影响。然而，贾第虫感染增加了钠和钾的摄取，这表明在贾第虫病引起的腹泻导致可能的高钠血症和低钾血症后，存在一种维持体内平衡的代偿机制。
