CHUV (Centre HospitalierUniversitaire Vaudois), Lausanne, Switzerland.
Department of Infectious Diseases, Central Institute, Valais Hospital, Sion, Switzerland.
Front Cell Infect Microbiol. 2021 Jan 28;10:619075. doi: 10.3389/fcimb.2020.619075. eCollection 2020.
Albeit the lungs were thought to be sterile, recent scientific data reported a microbial microbiota in the lungs of healthy individuals. Apparently, new developments in technological approachesincluding genome sequencing methodologies contributed in the identification of the microbiota and shed light on the role of the gut and lung microbiomes in the development of respiratory diseases. Moreover, knowledge of the human microbiome in health may act as a tool for evaluating characteristic shifts in the case of disease. This review paper discusses the development of respiratory disease linked to the intestinal dysbiosis which influences the lung immunity and microbiome. The gastrointestinal-lung dialogue provides interesting aspects in the pathogenesis of the respiratory diseases. Lastly, we were further interested on the role of this interconnection in the progression and physiopathology of newly emergedCOVID-19.
虽然人们一直认为肺部是无菌的，但最近的科学数据显示，健康个体的肺部存在微生物菌群。显然，技术方法的新发展，包括基因组测序方法，有助于识别微生物群，并揭示肠道和肺部微生物群在呼吸道疾病发展中的作用。此外，对健康人群微生物组的了解可以作为评估疾病特征变化的工具。本文讨论了与肠道菌群失调相关的呼吸道疾病的发展，肠道菌群失调影响肺部免疫和微生物组。胃肠道-肺部对话为呼吸道疾病的发病机制提供了有趣的方面。最后，我们还关注这种相互联系在新出现的 COVID-19 的进展和病理生理学中的作用。
