Pride Veterinary Centre, Riverside Road, Derby, Derbyshire, DE24 8HX, UK.
Vet Rec. 2012 Jun 23;170(25):648. doi: 10.1136/vr.100401. Epub 2012 Jun 1.
The acute phase proteins (APP) form part of a non-specific host response to inflammation. They may be induced by a range of different causes, including infection, inflammation, cancer and trauma. As they form part of the earliest response to such insults, they have potential for early identification of disease. In people, APP levels have been shown to correlate both with the extent of disease and also the prognosis in several forms of neoplasia, including prostate, oesophageal and colorectal cancer. As such, they can be used as prognostic and monitoring tools. To date, similar studies in veterinary patients have been limited, largely retrospective in nature and many are non-specific for tumour type. The purpose of this study was to evaluate a panel of four APPs in dogs with naturally occurring mast cell tumours (MCTs) and sarcomas to identify in the first instance whether increased levels of individual APPs, or identifiable combinations of APPs, was linked with the presence of disease. In the patients with MCTs, C-reactive protein (CRP) and α-1 acid glycoprotein levels increased, with a concurrent drop in serum amyloid A levels. In the sarcoma patients, CRP, α-1 acid glycoprotein and haptoglobin were increased. These findings suggest that specific solid tumour types in dogs may be associated with specific changes in APP profiles.
急性期蛋白（APP）是宿主对炎症的非特异性反应的一部分。它们可能由多种不同的原因引起，包括感染、炎症、癌症和创伤。由于它们构成了对这些损伤的最早反应的一部分，因此它们有可能早期识别疾病。在人类中，APP 水平与多种肿瘤的疾病程度和预后相关，包括前列腺癌、食管癌和结直肠癌。因此，它们可用作预后和监测工具。迄今为止，兽医患者的类似研究受到限制，主要是回顾性的，并且许多研究对肿瘤类型不具有特异性。本研究的目的是评估一组在患有自然发生的肥大细胞瘤（MCT）和肉瘤的犬中发现的四种 APP，以首先确定个体 APP 水平的升高，或可识别的 APP 组合是否与疾病的存在有关。在患有 MCT 的患者中，C 反应蛋白（CRP）和α-1 酸性糖蛋白水平升高，同时血清淀粉样蛋白 A 水平下降。在肉瘤患者中，CRP、α-1 酸性糖蛋白和触珠蛋白升高。这些发现表明，犬特定的实体瘤类型可能与 APP 谱的特定变化相关。
