Verleden G M, Vos R, Van Raemdonck D E, Laleman W, Vanaudenaerde B M
Lung Transplantation Unit, University Hospital Gasthuisberg, Leuven, Belgium.
Transplant Proc. 2012 Jun;44(5):1457-9. doi: 10.1016/j.transproceed.2011.12.077.
Most adults are Varicella zoster virus (VZV)-positive at the age of 20 years. Some, however, remain antibody-negative and may develop primary chicken pox during adulthood. We report a patient with Williams-Campbell syndrome who underwent double-lung transplantation while being VZV-negative. One year after the successful procedure, he was admitted with fulminant hepatic failure and some cutaneous vesicles in his face. Despite a rapid diagnosis of VZV infection and treatment with acyclovir, his situation deteriorated within 24 hours and while awaiting an urgent liver transplantation, he developed multiple organ failure and died.
大多数成年人在20岁时水痘带状疱疹病毒（VZV）呈阳性。然而，有些人仍为抗体阴性，可能在成年期发生原发性水痘。我们报告一名患有威廉姆斯 - 坎贝尔综合征的患者，在VZV阴性时接受了双肺移植。手术成功一年后，他因暴发性肝衰竭和面部出现一些皮肤水疱入院。尽管迅速诊断出VZV感染并使用阿昔洛韦治疗，但他的病情在24小时内恶化，在等待紧急肝移植期间，他出现多器官功能衰竭并死亡。
