Department of Psychology, Brooklyn College of City University of New York, Brooklyn, NY, USA.
Eur J Neurosci. 2012 Jun;35(11):1799-809. doi: 10.1111/j.1460-9568.2012.08113.x.
Four experiments examined the roles of the basolateral amygdala and orbitofrontal cortex in the formation of sensory-specific associations in conditioned flavor preference and conditioned magazine approach paradigms using unconditioned stimulus (US) devaluation and selective Pavlovian-instrumental transfer procedures in Long Evans rats. Experiment 1 found that pre-training amygdala and orbitofrontal cortex lesions had no detectable effect on the formation or flexible use of sensory-specific flavor-nutrient associations in a US devaluation task, where flavor cues were paired either simultaneously or sequentially with nutrient rewards in water-deprived subjects. In Experiment 2, pre-training amygdala and orbitofrontal cortex lesions both attenuated outcome-specific Pavlovian-instrumental transfer. Experiment 3 indicated that amygdala lesions have no effect on the formation of sensory-specific flavor-nutrient associations in a US devaluation task in food-deprived subjects. Finally, Experiment 4 demonstrated that the outcomes used in Experiment 3 were sufficiently motivationally significant to support conditioned flavor preference. These findings suggest that, although both orbitofrontal cortex and amygdala lesions attenuate the acquisition of sensory-specific associations in magazine approach conditioning, neither lesion reduces the ability to appropriately respond to a flavor cue that was paired with a devalued outcome.
四项实验使用未条件化刺激（US）贬值和选择性巴甫洛夫仪器转移程序，在长耳大鼠中检查了基底外侧杏仁核和眶额皮质在条件味觉偏好和条件杂志接近范式中形成感觉特异性关联中的作用。实验 1 发现，杏仁核和眶额皮质的预训练损伤对 US 贬值任务中感觉特异性风味-营养关联的形成或灵活使用没有可检测到的影响，在该任务中，风味线索要么与水剥夺的动物中的营养奖励同时配对，要么依次配对。在实验 2 中，预训练的杏仁核和眶额皮质损伤均减弱了特定结果的巴甫洛夫仪器转移。实验 3 表明，杏仁核损伤对食物剥夺的动物在 US 贬值任务中形成感觉特异性风味-营养关联没有影响。最后，实验 4 证明实验 3 中使用的结果足以支持条件风味偏好。这些发现表明，尽管杏仁核和眶额皮质损伤都削弱了杂志接近条件作用中感觉特异性关联的获得，但两种损伤都不会降低对与贬值结果配对的风味线索做出适当反应的能力。
