McDannald Michael A, Jones Joshua L, Takahashi Yuji K, Schoenbaum Geoffrey
National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, United States.
University of Maryland, School of Medicine, Baltimore, MD, United States.
Neurobiol Learn Mem. 2014 Feb;108:22-7. doi: 10.1016/j.nlm.2013.06.003. Epub 2013 Jun 14.
Since it was demonstrated the orbitofrontal cortex (OFC) is critical to reversal learning, there has been considerable interest in specifying its role in flexible, outcome-guided behavior. Behavioral paradigms from the learning theory tradition, such as outcome devaluation, blocking, Pavlovian to instrumental transfer, and overexpectation have been a driving force in this research. The use of these procedures has revealed OFC's unique role in forming and integrating information about specific features of events and outcomes to drive behavior and learning. These studies highlight the power and importance of learning theory principles in guiding neuroscience research.
自从有研究表明眶额皮质(OFC)对逆向学习至关重要以来,人们对明确其在灵活的、结果导向行为中的作用产生了浓厚兴趣。来自学习理论传统的行为范式,如结果贬值、阻断、巴甫洛夫式到工具性转移以及过度期望,一直是这项研究的驱动力。这些程序的使用揭示了眶额皮质在形成和整合有关事件和结果特定特征的信息以驱动行为和学习方面的独特作用。这些研究突出了学习理论原则在指导神经科学研究中的力量和重要性。