静息能量消耗和碳水化合物氧化在老年 COPD 患者中更高：一项病例对照研究。
Resting energy expenditure and carbohydrate oxidation are higher in elderly patients with COPD: a case control study.
机构信息
Universidade Metodista de Piracicaba, Lins, SP, Brazil.
出版信息
Nutr J. 2012 Jun 6;11:37. doi: 10.1186/1475-2891-11-37.
BACKGROUND
Elderly patients with chronic obstructive pulmonary disease (COPD) usually have a compromised nutritional status which is an independent predictor of morbidity and mortality. To know the Resting Energy Expenditure (REE) and the substrate oxidation measurement is essential to prevent these complications. This study aimed to compare the REE, respiratory quotient (RQ) and body composition between patients with and without COPD.
METHODS
This case-control study assessed 20 patients with chronic obstructive pulmonary disease attending a pulmonary rehabilitation program. The group of subjects without COPD (control group) consisted of 20 elderly patients attending a university gym, patients of a private service and a public healthy care. Consumption of oxygen (O₂) and carbon dioxide (CO₂) was determined by indirect calorimetry and used for calculating the resting energy expenditure and respiratory quotient. Body mass index (BMI) and waist circumference (WC) were also measured. Percentage of body fat (%BF), lean mass (kg) and muscle mass (kg) were determined by bioimpedance. The fat free mass index (FFMI) and muscle mass index (MMI) were then calculated.
RESULTS
The COPD group had lower BMI than control (p = 0.02). However, WC, % BF, FFMI and MM-I did not differ between the groups. The COPD group had greater RQ (p = 0.01), REE (p = 0.009) and carbohydrate oxidation (p = 0.002).
CONCLUSIONS
Elderly patients with COPD had higher REE, RQ and carbohydrate oxidation than controls.
背景
老年慢性阻塞性肺疾病（COPD）患者通常存在营养状况受损的情况，这是发病率和死亡率的独立预测因素。了解静息能量消耗（REE）和底物氧化测量对于预防这些并发症至关重要。本研究旨在比较有和无 COPD 的患者的 REE、呼吸商（RQ）和身体成分。
方法
这项病例对照研究评估了 20 名参加肺康复计划的慢性阻塞性肺疾病患者。无 COPD（对照组）的患者组由 20 名参加大学健身房、私人服务和公共健康保健的老年患者组成。通过间接测热法测定氧气（O₂）和二氧化碳（CO₂）的消耗，用于计算静息能量消耗和呼吸商。还测量了体重指数（BMI）和腰围（WC）。通过生物阻抗法确定体脂肪百分比（%BF）、瘦体重（kg）和肌肉量（kg）。然后计算无脂肪质量指数（FFMI）和肌肉质量指数（MMI）。
结果
COPD 组的 BMI 低于对照组（p=0.02）。然而，两组的 WC、%BF、FFMI 和 MMI 没有差异。COPD 组的 RQ（p=0.01）、REE（p=0.009）和碳水化合物氧化（p=0.002）更高。
结论
老年 COPD 患者的 REE、RQ 和碳水化合物氧化高于对照组。
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