中国维吾尔族慢性阻塞性肺疾病患者的血浆胃饥饿素水平与体重减轻

Plasma ghrelin levels and weight loss in Chinese Uygur patients with chronic obstructive pulmonary disease.

作者信息

Ying B W, Song X B, Fan H, Wang L L, Li Y S, Cheng Z, Cheng H, Wen F Q

机构信息

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

出版信息

J Int Med Res. 2008 Nov-Dec;36(6):1371-7. doi: 10.1177/147323000803600626.

DOI:10.1177/147323000803600626

PMID:19094448

Abstract

Ghrelin is an important orexigenic hormone that reduces fat oxidation and increases adiposity. This study investigated plasma ghrelin levels in Chinese Uygur patients with chronic obstructive pulmonary disease (COPD). Plasma ghrelin and anabolic and catabolic factors were measured in 38 patients and 24 control subjects. COPD patients were divided into two groups based on body mass index (BMI): underweight (BMI < 20 kg/m(2), n = 18) or normoweight (BMI > or = 20 kg/m(2), n = 20). Plasma ghrelin levels were found to be significantly higher in underweight than in normoweight patients or healthy controls. Circulating tumour necrosis factor-alpha and interleukin-6 concentrations were significantly higher in underweight than in normoweight patients, whereas insulin concentrations were significantly lower. Plasma ghrelin levels correlated negatively with forced expiratory volume in 1 s (FEV(1); r = 0.35), but did not significantly correlate with FEV(1)/forced vital capacity. Plasma ghrelin levels were elevated in underweight COPD patients and were associated with cachexia and abnormal pulmonary function.

摘要

胃饥饿素是一种重要的促食欲激素，它可减少脂肪氧化并增加肥胖程度。本研究调查了中国维吾尔族慢性阻塞性肺疾病（COPD）患者的血浆胃饥饿素水平。对38例患者和24名对照者测量了血浆胃饥饿素以及合成代谢和分解代谢因子。COPD患者根据体重指数（BMI）分为两组：体重过轻（BMI < 20 kg/m²，n = 18）或正常体重（BMI ≥ 20 kg/m²，n = 20）。发现体重过轻患者的血浆胃饥饿素水平显著高于正常体重患者或健康对照者。体重过轻患者循环中的肿瘤坏死因子-α和白细胞介素-6浓度显著高于正常体重患者，而胰岛素浓度显著较低。血浆胃饥饿素水平与1秒用力呼气量（FEV₁；r = 0.35）呈负相关，但与FEV₁/用力肺活量无显著相关性。体重过轻的COPD患者血浆胃饥饿素水平升高，且与恶病质和肺功能异常有关。