阿尔茨海默病影像学的最新进展。
Recent advances in imaging Alzheimer's disease.
机构信息
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095-7334, USA.
出版信息
J Alzheimers Dis. 2013;33 Suppl 1(0 1):S313-27. doi: 10.3233/JAD-2012-129016.
Abstract
Advances in brain imaging technology in the past five years have contributed greatly to the understanding of Alzheimer's disease (AD). Here, we review recent research related to amyloid imaging, new methods for magnetic resonance imaging analyses, and statistical methods. We also review research that evaluates AD risk factors and brain imaging, in the context of AD prediction and progression. We selected a variety of illustrative studies, describing how they advanced the field and are leading AD research in promising new directions.
摘要
在过去的五年中，脑成像技术的进步极大地促进了对阿尔茨海默病（AD）的理解。在这里，我们回顾了最近与淀粉样蛋白成像、磁共振成像分析新方法和统计方法相关的研究。我们还回顾了评估 AD 风险因素和脑成像的研究，以了解 AD 的预测和进展。我们选择了各种有代表性的研究，描述了它们如何推动该领域的发展，并引领 AD 研究朝着有前途的新方向发展。
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本文引用的文献
1
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2
Predicting white matter integrity from multiple common genetic variants.从多个常见遗传变异预测白质完整性。
Neuropsychopharmacology. 2012 Aug;37(9):2012-9. doi: 10.1038/npp.2012.49. Epub 2012 Apr 18.
3
Identification of common variants associated with human hippocampal and intracranial volumes.鉴定与人类海马体和颅内体积相关的常见变异。
Nat Genet. 2012 Apr 15;44(5):552-61. doi: 10.1038/ng.2250.
4
Multi-source feature learning for joint analysis of incomplete multiple heterogeneous neuroimaging data.多源特征学习用于联合分析不完全的多种异质神经影像数据。
Neuroimage. 2012 Jul 2;61(3):622-32. doi: 10.1016/j.neuroimage.2012.03.059. Epub 2012 Mar 29.
5
Pathologic lesions in neurodegenerative diseases.神经退行性疾病中的病理学病变。
Prog Mol Biol Transl Sci. 2012;107:1-40. doi: 10.1016/B978-0-12-385883-2.00009-6.
6
Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene.健康成年人的大脑结构与血清转铁蛋白和 HFE 基因中的 H63D 多态性有关。
Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):E851-9. doi: 10.1073/pnas.1105543109. Epub 2012 Jan 9.
7
Sparse reduced-rank regression detects genetic associations with voxel-wise longitudinal phenotypes in Alzheimer's disease.稀疏降秩回归检测阿尔茨海默病中体素水平纵向表型的遗传关联。
Neuroimage. 2012 Mar;60(1):700-16. doi: 10.1016/j.neuroimage.2011.12.029. Epub 2011 Dec 22.
8
The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects.多基因阿尔茨海默评分与临床正常受试者皮质厚度的相关性。
Cereb Cortex. 2012 Nov;22(11):2653-61. doi: 10.1093/cercor/bhr348. Epub 2011 Dec 13.
9
Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variant.CLU 阿尔茨海默病风险变异体健康携带者的海马功能。
J Neurosci. 2011 Dec 7;31(49):18180-4. doi: 10.1523/JNEUROSCI.4960-11.2011.
10
Predicting MCI outcome with clinically available MRI and CSF biomarkers.用临床可用的 MRI 和 CSF 生物标志物预测 MCI 结局。
Neurology. 2011 Oct 25;77(17):1619-28. doi: 10.1212/WNL.0b013e3182343314. Epub 2011 Oct 12.
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