Mechanical and Industrial Engineering Department, The University of Iowa, 2130 Seamans Center, Iowa City, IA 52242, USA.
Comput Methods Programs Biomed. 2012 Dec;108(3):922-31. doi: 10.1016/j.cmpb.2012.05.004. Epub 2012 Jun 4.
This paper presents localized and temporal control of release kinetics over 3-dimensional (3D) hybrid wound devices to improve wound-healing process. Imaging study is performed to extract wound bed geometry in 3D. Non-Uniform Rational B-Splines (NURBS) based surface lofting is applied to generate functionally graded regions. Diffusion-based release kinetics model is developed to predict time-based release of loaded modifiers for functionally graded regions. Multi-chamber single nozzle solid freeform dispensing system is used to fabricate wound devices with controlled dispensing concentration. Spatiotemporal control of biological modifiers thus enables a way to achieve target delivery to improve wound healing.
本文提出了一种针对三维（3D）混合伤口装置的局部和时间控制释放动力学的方法，以改善伤口愈合过程。通过成像研究提取 3D 伤口床几何形状。应用非均匀有理 B 样条（NURBS）基于曲面放样生成功能梯度区域。开发基于扩散的释放动力学模型，以预测功能梯度区域中加载调节剂的基于时间的释放。使用多腔单喷嘴无模自由成型分配系统制造具有受控分配浓度的伤口装置。因此，生物修饰剂的时空控制为实现靶向输送以改善伤口愈合提供了一种方法。
