University of Eastern Finland, Institute of Public Health and Clinical Nutrition, Kuopio, Finland.
Hypertens Res. 2012 Oct;35(10):1000-4. doi: 10.1038/hr.2012.80. Epub 2012 Jun 7.
Fish or fish oil consumption has been associated with lower blood pressure. Fish may also contain methylmercury, which has been associated with cardiovascular diseases and higher blood pressure. Our aim was to study the associations of serum long-chain n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), mainly reflecting fish or fish oil intake, and hair mercury concentration with blood pressure. Data were available for 848 men and 909 women from the Kuopio Ischaemic Heart Disease Risk Factor Study, aged 53-73 years. We excluded participants with ischemic heart disease, stroke, diabetes or hypertension treatment, leaving 396 men and 372 women. Log-transformed values were used to study the associations. The mean serum concentrations were 1.63% (s.d. 0.91) for EPA, 0.77% (s.d. 0.16) for DPA and 2.73% (s.d. 0.90) for DHA of all serum fatty acids. Multivariate-adjusted serum EPA+DPA+DHA was associated with lower systolic blood pressure (β = -4.50, 95% confidence interval (CI) -8.02 - -0.99) and pulse pressure (β = -4.41, 95% CI -6.95 - -1.87), but not with diastolic blood pressure (β = -0.45, 95% CI -2.31-1.52). The associations were similar with EPA, DPA and DHA evaluated individually. The mean hair mercury concentration was 1.42 μg g(-1) (s.d. 1.54). Hair mercury was not associated with blood pressure and it did not modify the association between PUFA and blood pressure. These results suggest that higher serum long-chain n-3 PUFA concentration has a modest inverse association with blood pressure in older men and women.
鱼类或鱼油的摄入与较低的血压有关。鱼类中可能还含有甲基汞，它与心血管疾病和较高的血压有关。我们的目的是研究血清长链 n-3 多不饱和脂肪酸（PUFA）二十碳五烯酸（EPA）、二十二碳五烯酸（DPA）和二十二碳六烯酸（DHA）与血压的关系，这些物质主要反映了鱼类或鱼油的摄入情况，以及头发中的汞浓度与血压的关系。数据来自于年龄在 53-73 岁的库奥皮奥缺血性心脏病危险因素研究中的 848 名男性和 909 名女性。我们排除了患有缺血性心脏病、中风、糖尿病或高血压治疗的参与者，留下了 396 名男性和 372 名女性。使用对数转换值来研究相关性。所有血清脂肪酸的血清 EPA+DPA+DHA 的平均浓度为 1.63%（标准差 0.91），DPA 为 0.77%（标准差 0.16），DHA 为 2.73%（标准差 0.90）。多变量调整后的血清 EPA+DPA+DHA 与收缩压（β=-4.50，95%置信区间（CI）-8.02- -0.99）和脉压（β=-4.41，95% CI-6.95- -1.87）降低相关，但与舒张压（β=-0.45，95% CI-2.31-1.52）无关。单独评估 EPA、DPA 和 DHA 时，结果相似。头发中汞的平均浓度为 1.42μg/g（标准差 1.54μg/g）。头发中的汞与血压无关，也不能改变 PUFA 与血压之间的关系。这些结果表明，在老年男性和女性中，较高的血清长链 n-3 PUFA 浓度与血压呈适度负相关。
