Jyrki K. Virtanen, University of Eastern Finland, Kuopio Campus, Institute of Public Health and Clinical Nutrition, PO Box 1627, 70211 Kuopio, Finland, +358 (0) 294454542 / +358 (0) 403552957 Fax +358-17-162936. E-mail:
J Nutr Health Aging. 2015 May;19(5):498-503. doi: 10.1007/s12603-015-0463-6.
To investigate the associations of serum long-chain omega-3 polyunsaturated fatty acids (PUFA) and hair mercury with future blood pressure in an ageing population.
Prospective study with baseline measurements in 1998-2001 and follow-up measurements in 2005-2008. The linear relationships (β) of baseline serum fatty acids and hair mercury with future systolic and diastolic blood pressure and pulse pressure were analyzed with multiple linear regression models, using log-transformed values.
181 men and 200 women aged 53-73 y from the Kuopio Ischemic Heart Disease Risk Factor Study (KIHD) population in Eastern Finland, who were free of cardiovascular disease, diabetes or hypertension at baseline.
Total serum esterified and nonesterified fatty acids and pubic hair mercury were used as markers for exposure. Anthropometric and other lifestyle and health-related data were collected.
The mean serum concentrations were 1.67% (SD 0.92) for eicosapentaenoic acid (EPA), 0.79% (SD 0.16) for docosapentaenoic acid (DPA) and 2.78 (SD 0.92) for docosahexaenoic acid (DHA), of all serum fatty acids. The mean hair mercury concentration was 1.5 µg/g (SD 1.6). We did not find statistically significant associations between the baseline serum long-chain omega-3 PUFA concentrations or hair mercury content and future blood pressure. Hair mercury did not modify the associations with the long-chain omega-3 PUFAs, either.
Higher serum long-chain omega-3 PUFA concentration, a biomarker of fish or fish oil consumption, may not have an impact on future blood pressure in an ageing population.
在老龄化人群中，研究血清长链 ω-3 多不饱和脂肪酸（PUFA）和头发汞与未来血压之间的关联。
1998-2001 年进行基线测量，2005-2008 年进行随访测量的前瞻性研究。采用多元线性回归模型，对基线血清脂肪酸和头发汞与未来收缩压、舒张压和脉压的线性关系（β）进行分析，采用对数转换值。
来自芬兰东部库奥皮奥缺血性心脏病风险因素研究（KIHD）人群的 181 名男性和 200 名女性，年龄 53-73 岁，基线时无心血管疾病、糖尿病或高血压。
总血清酯化和非酯化脂肪酸和阴毛头发汞用作暴露标志物。收集人体测量和其他生活方式以及与健康相关的数据。
血清中所有脂肪酸的平均浓度为二十碳五烯酸（EPA）1.67%（SD 0.92），二十二碳五烯酸（DPA）0.79%（SD 0.16）和二十二碳六烯酸（DHA）2.78%（SD 0.92）。头发汞的平均浓度为 1.5μg/g（SD 1.6）。我们没有发现基线血清长链 ω-3PUFA 浓度或头发汞含量与未来血压之间存在统计学显著关联。头发汞也没有改变与长链 ω-3PUFA 的关联。
较高的血清长链 ω-3PUFA 浓度，即鱼类或鱼油消费的生物标志物，可能不会对老龄化人群的未来血压产生影响。
