Vasioukhin Valeri
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA,
Subcell Biochem. 2012;60:379-414. doi: 10.1007/978-94-007-4186-7_16.
Cadherins and catenins are the central cell-cell adhesion molecules in adherens junctions (AJs). This chapter reviews the knowledge concerning the role of cadherins and catenins in epithelial cancer and examines the published literature demonstrating the changes in the expression and function of these proteins in human cancer and the association of these changes with patient outcomes. The chapter also covers the mechanistic studies aiming at uncovering the significance of changes in cadherin and catenin expression in cancer and potential molecular mechanisms responsible for the causal role of AJs in cancer initiation and progression.
钙黏蛋白和连环蛋白是黏着连接（AJs）中的核心细胞间黏附分子。本章回顾了关于钙黏蛋白和连环蛋白在上皮癌中作用的知识，并审视了已发表的文献，这些文献展示了这些蛋白质在人类癌症中的表达和功能变化，以及这些变化与患者预后的关联。本章还涵盖了旨在揭示钙黏蛋白和连环蛋白表达变化在癌症中的意义以及负责AJs在癌症起始和进展中因果作用的潜在分子机制的机制研究。
