Neurology Service, Erzincan Military Hospital, Erzincan, Turkey.
J Rehabil Med. 2012 Jun;44(7):601-4. doi: 10.2340/16501977-0990.
The aim of this trial was to compare the efficacy of triamcinolone acetonide and procaine HCl with that of placebo in the treatment of carpal tunnel syndrome.
This prospective, randomized placebo-controlled trial included 57 patients (90 median nerves). Ninety median nerves were randomly assigned to 1 of 3 groups: group 1 was injected with 1 ml 0.09% saline, group 2 was injected with 40 mg triamcinolone acetonide, and group 3 was injected with 4 ml 1% procaine HCl. Clinical and electrophysiological evaluations were performed at study onset, and at 2 and 6 months post-treatment.
At study onset no significant differences were observed between groups with respect to clinical and electrophysiological parameters. Clinical and electrophysiological evaluations was improved significantly in groups 2 and 3 at post-treatment (p<0.05). No significant changes were observed in group 1 (p>0.05). Moreover, groups 2 and 3 had better scores than group 1 at 2 and 6 months post-treatment(p<0.05). There was no difference between groups 2 and 3 in terms of change scores of any terms at post-treatment (p>0.05).
Triamcinolone acetonide and procaine HCl injections are effective regarding short- and long-term outcomes compared with placebo injections, and procaine HCl injection was as effective as steroid injection.
本试验旨在比较曲安奈德和盐酸普鲁卡因与安慰剂治疗腕管综合征的疗效。
前瞻性、随机、安慰剂对照试验纳入了 57 例（90 条正中神经）患者。90 条正中神经随机分为 3 组：第 1 组注射 1ml0.09%生理盐水，第 2 组注射 40mg 曲安奈德，第 3 组注射 4ml1%盐酸普鲁卡因。在研究开始时、治疗后 2 个月和 6 个月进行临床和电生理评估。
在研究开始时，各组之间的临床和电生理参数无显著差异。治疗后第 2 和第 6 个月，第 2 组和第 3 组的临床和电生理评估均显著改善（p<0.05）。第 1 组无明显变化（p>0.05）。此外，治疗后 2 个月和 6 个月，第 2 组和第 3 组的评分均优于第 1 组（p<0.05）。治疗后，第 2 组和第 3 组的任何指标的变化评分均无差异（p>0.05）。
与安慰剂注射相比，曲安奈德和盐酸普鲁卡因注射在短期和长期结果方面均有效，且盐酸普鲁卡因注射与类固醇注射同样有效。
