Department of Neurology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Mov Disord. 2012 Jul;27(8):974-9. doi: 10.1002/mds.25016. Epub 2012 Jun 1.
Several metabolic markers or conditions have been explored as possible risk or protective factors for Parkinson's disease (PD); however, results remain conflicting. We further investigated these associations using a case-control study design. We used the medical records-linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995. Each incident case was matched by age (±1 year) and sex to a general population control. We reviewed the complete medical records of cases and controls in the medical records-linkage system to abstract information about body mass index (BMI), cholesterol level, hypertension, and diabetes mellitus preceding the onset of PD (or the index year). There were no significant differences between cases and controls for the metabolic markers or conditions investigated. No significant associations were found using 2 cutoffs for BMI level (BMI ≥ 25 or BMI ≥ 30 kg/m(2) ) and 3 cutoffs for cholesterol levels (>200, >250, or >300 mg/dL). Neither a diagnosis of hypertension or the documented use of antihypertensive medications was significantly associated with the subsequent risk of PD (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.65-1.54; P = .99) nor was a diagnosis of diabetes mellitus or the use of glucose-lowering medications (OR, 0.77; 95% CI, 0.37-1.57; P = .47). Our study, based on historical information from a records-linkage system, does not support an association between BMI, cholesterol level, hypertension, or diabetes mellitus with later development of PD.
一些代谢标志物或状况已被探索作为帕金森病（PD）的可能风险或保护因素；然而，结果仍然存在争议。我们使用病例对照研究设计进一步研究了这些关联。我们利用罗切斯特流行病学项目的病历链接系统，确定了 196 名在明尼苏达州罗切斯特县于 1976 年至 1995 年间发生 PD 的患者。每个新发病例都与年龄（±1 岁）和性别相匹配的一般人群对照相匹配。我们在病历链接系统中审查了病例和对照的完整病历，以提取 PD 发病前（或索引年）的体重指数（BMI）、胆固醇水平、高血压和糖尿病的信息。在研究的代谢标志物或状况方面，病例和对照之间没有显著差异。使用 BMI 水平（BMI≥25 或 BMI≥30 kg/m(2)）的 2 个切点和胆固醇水平（>200、>250 或>300 mg/dL）的 3 个切点，均未发现显著相关性。高血压的诊断或降压药物的使用与 PD 发生风险无显著相关性（比值比 [OR]，1.00；95%置信区间 [CI]，0.65-1.54；P=.99），糖尿病的诊断或降糖药物的使用也无显著相关性（OR，0.77；95% CI，0.37-1.57；P=.47）。我们的研究基于病历链接系统中的历史信息，不支持 BMI、胆固醇水平、高血压或糖尿病与 PD 后发病之间的关联。
