Dipartimento Universitario di Neuroscienze Cliniche, Via Gaetano La Loggia 1, 90129 Palermo, Italy.
Parkinsonism Relat Disord. 2009 Nov;15(9):660-4. doi: 10.1016/j.parkreldis.2009.02.013. Epub 2009 Apr 7.
To assess the association between diabetes preceding Parkinson's disease (PD) and PD.
PD individuals were matched to PD free individuals randomly selected from people in the same municipality as the cases. Occurrence of diabetes preceding PD onset among cases and controls was assessed through a structured questionnaire. Information regarding current and past medical treatment and other variables was also collected. We used univariate and multivariate logistic models to calculate crude and adjusted odds ratios (OR). Covariates are adjusted for included education, smoking habit, alcohol and coffee consumption.
318 PD individuals (165 women, 153 men) and 318 matched controls were included in the study. PD patients had a mean age at interview of 66.7 years. Mean age at PD onset was 60.8 years and mean PD duration 5.9 years. We found an inverse association between PD and diabetes preceding PD onset in all groups stratified by gender, age at PD onset, body mass index (BMI), smoking habit, alcohol and coffee consumption. Multivariate analysis yielded the same findings after controlling for the variables (adjusted OR 0.4; 95% CI, 0.2-0.8).
Our findings provide additional support for a potential link between diabetes and PD.
评估糖尿病先于帕金森病（PD）与 PD 之间的关联。
将 PD 患者与同市随机选择的 PD 患者相匹配。通过结构化问卷评估病例和对照组中 PD 发病前发生糖尿病的情况。还收集了有关当前和过去的医疗治疗以及其他变量的信息。我们使用单变量和多变量逻辑模型计算了粗比值比（OR）和调整比值比（OR）。协变量调整包括教育、吸烟习惯、酒精和咖啡消耗。
本研究纳入了 318 名 PD 患者（165 名女性，153 名男性）和 318 名匹配的对照者。PD 患者的访谈平均年龄为 66.7 岁。PD 发病的平均年龄为 60.8 岁，平均 PD 病程为 5.9 年。我们发现，在按性别、PD 发病年龄、体重指数（BMI）、吸烟习惯、酒精和咖啡消耗分层的所有组中，PD 与 PD 发病前的糖尿病之间存在负相关。在控制了变量（调整后的 OR 0.4；95%CI，0.2-0.8）后，多变量分析得出了相同的结果。
我们的研究结果为糖尿病与 PD 之间存在潜在联系提供了额外的证据。
