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坏死梭杆菌——超越勒米耶综合征

Fusobacterium necrophorum--beyond Lemierres syndrome.

作者信息

Shahani Lokesh, Khardori Nancy

机构信息

Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, Illinois, United States.

出版信息

BMJ Case Rep. 2011 Nov 15;2011:bcr0720114527. doi: 10.1136/bcr.07.2011.4527.

Abstract

Fusobacterium necrophorum is a non-sporulating anaerobic gram negative bacillus and has traditionally been associated with Lemierre's syndrome. The authors report a 34-year-old male who presented to the emergency department with a week's history of dull epigastirc pain. Significant medical history included chronic pancreatitis secondary to alcohol use. The patient had radiological evidence of acute on chronic pancreatitis with thrombosis of the portal vein and multiple intrahepatic abscesses. CT-guided drainage of left upper quadrant revealed fluid collection in the pancreatic bed. The fluid culture grew F necrophorum and the patient was treated with tigecycline for 4 weeks. The patient improved symptomatically and his follow-up computerised axial tomography scan 2 months later showed resolving liver abscess, cavernous transformation of the portal vein and stable findings of chronic pancreatitis. This could represent an infection of the peripancreatic tissue with F necrophorum further leading to pylephlebitis.

摘要

坏死梭杆菌是一种无芽孢的厌氧革兰氏阴性杆菌,传统上与勒米尔综合征有关。作者报告了一名34岁男性,他因一周的上腹部隐痛病史就诊于急诊科。重要病史包括酒精性慢性胰腺炎。患者有慢性胰腺炎急性发作伴门静脉血栓形成和多个肝内脓肿的影像学证据。CT引导下对上腹象限进行引流,发现胰腺床有积液。积液培养出坏死梭杆菌,患者接受替加环素治疗4周。患者症状改善,2个月后的随访计算机断层扫描显示肝脓肿消退、门静脉海绵样变性以及慢性胰腺炎表现稳定。这可能代表坏死梭杆菌感染胰周组织,进而导致门静脉炎。

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本文引用的文献

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Septic portal vein thrombosis due to Fusobacterium necrophorum.
Aust N Z J Med. 1999 Aug;29(4):569-70. doi: 10.1111/j.1445-5994.1999.tb00766.x.
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Clin Infect Dis. 1999 Jun;28(6):1325-6. doi: 10.1086/517785.
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