在苏丹中部，用吡喹酮治疗一年后，在校儿童中的曼氏血吸虫感染。
Schistosoma haematobium infections among schoolchildren in central Sudan one year after treatment with praziquantel.
机构信息
Schistosomiasis Research Laboratory, Faculty of Science, University of Khartoum, Khartoum, Sudan.
出版信息
Parasit Vectors. 2012 Jun 7;5:108. doi: 10.1186/1756-3305-5-108.
BACKGROUND
Chemotherapy with praziquantel (PZQ) is the mainstay of schistosomiasis control. However, there are recent concerns about tolerance or resistance to PZQ, so that monitoring its efficacy in different settings is required.
METHODS
A longitudinal study was conducted to evaluate the impact of PZQ for the treatment of Schistosoma haematobium infection among schoolchildren at Al Salamania, Central Sudan. Parasitological examinations for S. haematobium were performed in a cohort of schoolchildren (6-15 years of age) before and 1 year after treatment with a single dose of PZQ 40 mg/kg.
RESULTS
Out of 562 (309 boys and 253 girls) schoolchildren recruited from three elementary schools, 420 completed one longitudinal dataset that comprised of data from two time points; baseline, and follow-up 1 year after treatment with a single dose of PZQ 40 mg/kg for S. haematobium infection. A single dose of PZQ significantly reduced the prevalence of S. haematobium infection by 83.3% (from 51.4% to 8.6%) and the geometric mean intensity of infection of positive individuals by 17.0% (from 87.7 to 72.8 eggs/10 ml of urine) 1 year after treatment. While there was no significant difference in the reduction of the prevalence of S. haematobium infection between the gender or age groups, there was a significantly higher reduction of intensity of S. haematobium infection among girls in comparison with boys.
CONCLUSION
There was a significant reduction of S. haematobium infection 1 year after PZQ treatment in this setting.
背景
以吡喹酮（PZQ）为基础的化疗是控制血吸虫病的主要方法。然而，最近人们对 PZQ 的耐受性或耐药性表示担忧，因此需要在不同环境中监测其疗效。
方法
在苏丹中部的 Al Salamania，进行了一项纵向研究，以评估吡喹酮治疗儿童曼氏血吸虫感染的效果。对来自三所小学的一组 6-15 岁儿童进行曼氏血吸虫寄生虫学检查，在单次服用 40mg/kg PZQ 治疗前后进行。
结果
从 562 名（309 名男孩和 253 名女孩）小学生中招募了 420 名儿童完成了一个纵向数据集，该数据集由基线和随访 1 年两个时间点的数据组成，对他们进行了一次服用 40mg/kg PZQ 治疗曼氏血吸虫感染。单次服用 PZQ 可显著降低曼氏血吸虫感染的患病率 83.3%（从 51.4%降至 8.6%），并将阳性个体的感染几何均数降低 17.0%（从 87.7 降至 72.8 个/10ml 尿液），在治疗后 1 年。尽管性别或年龄组之间曼氏血吸虫感染的患病率降低没有显著差异，但与男孩相比，女孩的感染强度降低更为显著。
结论
在这种情况下，吡喹酮治疗后 1 年，曼氏血吸虫感染显著减少。
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