德国结直肠癌发病率：结肠镜筛查计划实施 6 年后的阶段转移。
Colorectal cancer incidence in Germany: stage-shift 6 years after implementation of a colonoscopy screening program.
机构信息
Institute of Clinical Epidemiology, University Hospital Schleswig-Holstein, Campus Luebeck, RatzeburgerAllee 160, 23562 Luebeck, Germany.
出版信息
Cancer Epidemiol. 2012 Oct;36(5):417-20. doi: 10.1016/j.canep.2012.04.008. Epub 2012 Jun 5.
BACKGROUND
In 2002, colonoscopy was introduced as a tool for colorectal cancer screening in Germany. The long-term objective was to reduce the incidence in colorectal cancer (CRC) by detection and removal of advanced adenomas. Currently, the effect of colonoscopy screening on the population-based incidence of CRC in Germany is unknown.
METHODS
We provide data on stage-specific (age-standardized) incidence rates in three federal states in Germany, 6 years after the implementation of colonoscopy.
RESULTS
Between 2002 and 2008 a statistically significant decrease in CRC incidence could be observed (annually 3.0%, 95% confidence interval [CI]: -3.8; -2.2). The decline could be observed in all advanced tumor categories (T2, T3, and T4), whereas the incidence of in situ carcinomas (Tis) increased annually by 51.6% (95% CI: 28.0; 79.4) until 2004, and remained stable until 2008.
CONCLUSION
The observed changes cannot be attributed definitively to the screening activities, but the presented data support a possible causal association.
背景
2002 年，结肠镜检查被引入德国，作为结直肠癌筛查的一种手段。长期目标是通过检测和切除高级腺瘤来降低结直肠癌（CRC）的发病率。目前，结肠镜筛查对德国基于人群的 CRC 发病率的影响尚不清楚。
方法
我们提供了德国三个联邦州在结肠镜检查实施 6 年后特定阶段（年龄标准化）发病率的数据。
结果
2002 年至 2008 年间，CRC 的发病率呈统计学显著下降（每年 3.0%，95%置信区间 [CI]：-3.8%；-2.2%）。下降可在所有高级肿瘤类别（T2、T3 和 T4）中观察到，而原位癌（Tis）的发病率在 2004 年之前每年增加 51.6%（95%CI：28.0%；79.4%），并在 2008 年之前保持稳定。
结论
观察到的变化不能明确归因于筛查活动，但所提供的数据支持可能存在因果关系。
Zotero 插件