Oudot C, Lajoix A-D, Jover B, Rugale C
Centre de pharmacologie et innovation dans le diabète, FRE 3400 Montpellier, université de Montpellier, 34093 Montpellier, France.
Ann Cardiol Angeiol (Paris). 2012 Jun;61(3):162-6. doi: 10.1016/j.ancard.2012.04.017. Epub 2012 May 15.
The aim of this work was to evaluate the influence of dietary sodium restriction on metabolic and renal changes associated with insulin resistance. At 8 weeks of age, rats received either a diet containing 60% fructose with or without sodium or a standard diet for 12 weeks. The insulin resistance and albuminuria induced by the high fructose diet were associated with a fibrosis and increase in oxidative stress in the kidney. The low salt diet prevented insulin resistance, renal fibrosis and albuminuria induced by the fructose diet. These beneficial effects on the kidney were associated with a decrease in kidney NADPH oxidase activity. Oxidative status is probably one of the major targets of the favourable effect of salt restriction on renal changes associated with insulin resistance, without excluding the involvement of other mechanisms.
这项工作的目的是评估饮食中钠限制对与胰岛素抵抗相关的代谢和肾脏变化的影响。8周龄时，大鼠接受含60%果糖且含或不含钠的饮食或标准饮食12周。高果糖饮食诱导的胰岛素抵抗和蛋白尿与肾脏纤维化及氧化应激增加有关。低盐饮食可预防果糖饮食诱导的胰岛素抵抗、肾纤维化和蛋白尿。这些对肾脏的有益作用与肾脏NADPH氧化酶活性降低有关。氧化状态可能是盐限制对与胰岛素抵抗相关的肾脏变化产生有利影响的主要靶点之一，同时也不排除其他机制的参与。
