5-羧甲基-7-羟基-2-戊基色酮、5-羧乙基-4',7-二羟基黄酮及其类似物的合成及生物评价。

Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues.

机构信息

Division of Organic Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500607, India.

出版信息

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4891-5. doi: 10.1016/j.bmcl.2012.05.007. Epub 2012 May 23.

DOI:10.1016/j.bmcl.2012.05.007

Abstract

In this letter, we describe the first synthesis of two recently isolated flavones 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone (3a), 5-carboethoxymethyl-4',7-dihydroxyflavone (3b) and their derivatives (3c-t), evaluated for their antimicrobial, antioxidant and anticancer activities. Most of the synthesized compounds exhibited antimicrobial activity against the tested microbial strains and some of these compounds were found to be more potent as compared to the standard drugs like neomycin and luteolin. Interestingly, some of these synthesized compounds also showed moderate antioxidant property.

摘要

在这封信中，我们描述了最近分离的两种黄酮类化合物 5-羧甲基-7-羟基-2-戊基色酮（3a）、5-羧乙酯基-4'，7-二羟基黄酮（3b）及其衍生物（3c-t）的首次合成，并评估了它们的抗菌、抗氧化和抗癌活性。大多数合成化合物对测试的微生物菌株表现出抗菌活性，其中一些化合物的活性比新霉素和木犀草素等标准药物更强。有趣的是，这些合成化合物中的一些还表现出适度的抗氧化特性。