Laboratory of Reproductive Biology, Institute of Biotechnology, Academy of Sciences of the Czech Republic, vvi, Prague 4, Czech Republic.
Reprod Toxicol. 2013 Jan;35:32-9. doi: 10.1016/j.reprotox.2012.05.095. Epub 2012 Jun 4.
Tetrabromobisphenol A (TBBPA) is a substance widely used in industry as a flame retardant. TBBPA was found in the environment and was detected even in the human body. The effect of this chemical was observed in different cell lines in vitro and it is supposed that TBBPA may affect various hormonal systems in vivo. In this study we examined the effect of TBBPA on the reproductive parameters of two generations of outbred mice in vivo. Experimental and control animals of F1 generation were bred in various conditions to enable evaluation of the possible trans-generational effect. An increased incidence of apoptosis in the testes and changes in the morphometry of seminiferous tubules was detected in the experimental animals. In addition, changes in the expression pattern of selected genes encoding proteins that play an important role during spermatogenesis were observed. In contrast, sperm quality and reproduction were not affected by TBBPA.
四溴双酚 A（TBBPA）是一种广泛应用于工业的阻燃剂。TBBPA 在环境中被发现，甚至在人体内也被检测到。这种化学物质的影响在体外的不同细胞系中被观察到，据推测 TBBPA 可能会影响体内的各种激素系统。在这项研究中，我们研究了 TBBPA 对两代杂交小鼠体内生殖参数的影响。F1 代的实验和对照动物在不同的条件下繁殖，以评估可能的跨代效应。在实验动物的睾丸中检测到细胞凋亡的发生率增加和生精小管形态计量的变化。此外，观察到编码在精子发生过程中发挥重要作用的蛋白质的选定基因的表达模式发生变化。相比之下，TBBPA 不影响精子质量和繁殖。
