Department of Dermatology, Stanford School of Medicine, Stanford, California, USA.
J Am Acad Dermatol. 2012 Dec;67(6):1335-41. doi: 10.1016/j.jaad.2012.04.013. Epub 2012 Jun 5.
Malignant fibrous histiocytoma (MFH) is a rare neoplasm exhibiting a propensity for aggressive clinical behavior. This review seeks to provide the practicing dermatologist with a contemporary understanding of MFH in order to guide management decisions. An extensive review of the literature was conducted using PubMed and OVID databases, searching for articles regarding MFH and undifferentiated pleomorphic sarcoma. The modern conception of MFH has changed extensively from clinical and pathologic standpoints. Limitations of the study included the reliability of past studies given the changing nature of MFH as a diagnostic entity. MFH represents an aggressive neoplasm with unique molecular, immunohistochemical, and behavioral characteristics. Practicing clinicians would benefit from a contemporary understanding of these tumors, particularly as a discussion of advances in the conception of MFH is largely absent in the dermatologic literature.
恶性纤维组织细胞瘤（MFH）是一种罕见的肿瘤，表现出侵袭性的临床行为倾向。本综述旨在为皮肤科医生提供对 MFH 的现代认识，以指导治疗决策。使用 PubMed 和 OVID 数据库对文献进行了广泛的回顾，搜索了关于 MFH 和未分化多形性肉瘤的文章。从临床和病理的角度来看，现代 MFH 的概念发生了很大的变化。研究的局限性在于，鉴于 MFH 作为一个诊断实体的性质不断变化，过去的研究的可靠性。MFH 是一种具有独特分子、免疫组织化学和行为特征的侵袭性肿瘤。临床医生如果对这些肿瘤有一个现代的认识，将会受益匪浅，特别是因为在皮肤科文献中，对 MFH 概念的进展讨论几乎没有。
