Laboratoire d'Ecophysiologie Animale, Sfax, Tunisia.
J Trace Elem Med Biol. 2012 Oct;26(4):273-8. doi: 10.1016/j.jtemb.2012.04.002. Epub 2012 Jun 6.
The purpose of this study, carried out on male Wistar rats, was to evaluate the beneficial effects of supplementation with ascorbic acid (Vit C) and α-tocopherol (Vit E) or with Mg and Zn upon lindane-induced damages in liver and brain. Under our experimental conditions, lindane poisoning (5mg/kg body weight per day for 3 days) resulted in (1) an increased level of plasma glucose, cholesterol and triglycerides, (2) an increased activity of LDH, ALP, AST, ALT, (3) an oxidative stress in liver and brain as revealed by an increased level of lipids peroxidation (TBARS) and a decrease of glutathione-peroxidase, superoxide dismutase and catalase activities in liver and brain. In conclusion, both Vit C+E or Mg+Zn treatments display beneficial effects upon oxidative stress induced by lindane treatment in liver and brain.
本研究旨在评估补充抗坏血酸（维生素 C）和α-生育酚（维生素 E）或镁和锌对雄性 Wistar 大鼠因林丹引起的肝和脑损伤的有益作用。在我们的实验条件下，林丹中毒（每天 5mg/kg 体重，连续 3 天）导致（1）血浆葡萄糖、胆固醇和甘油三酯水平升高，（2）LDH、ALP、AST、ALT 活性升高，（3）肝和脑的氧化应激，表现为脂质过氧化（TBARS）水平升高，肝和脑的谷胱甘肽过氧化物酶、超氧化物歧化酶和过氧化氢酶活性降低。总之，维生素 C+E 或镁+锌治疗对林丹处理引起的肝和脑氧化应激均显示出有益作用。
