Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands.
J Am Soc Nephrol. 2012 Jul;23(7):1136-9. doi: 10.1681/ASN.2012010099. Epub 2012 Jun 7.
Current treatment of kidney disease is not completely satisfactory, particularly when initiated in the late stages of renal progression. There is an urgent need for additional interventions, especially reduction of salt intake, which is rather high in the Western world. In this commentary we provide a critical assessment of post hoc analyses of recent interventional and observational studies on the effect of salt intake on renal and cardiovascular outcomes. To evaluate the mechanisms and safety of reduced salt intake, studies specifically designed to assess salt intake as an endpoint are needed. This approach will have implications for health care policies and labeling of the salt content of purchased foods.
目前对肾病的治疗尚不完全令人满意，尤其是在肾脏进展的晚期开始治疗时。迫切需要额外的干预措施，特别是减少盐的摄入，而在西方国家盐的摄入量相当高。在这篇评论中，我们对最近关于盐摄入量对肾脏和心血管结局影响的干预和观察研究的事后分析进行了批判性评估。为了评估减少盐摄入的机制和安全性，需要专门设计评估盐摄入量作为终点的研究。这种方法将对医疗保健政策和购买食品的盐含量标签产生影响。
