Department of Ophthalmology, St Thomas' Hospital, London, UK.
Eye (Lond). 2012 Aug;26(8):1114-21. doi: 10.1038/eye.2012.112. Epub 2012 Jun 8.
To investigate whether pseudophakic and phakic rhegmatogenous retinal detachment (RRD) patterns differ.
Retrospective review of electronic database of patients, aged 50 years or over, presenting to our vitreoretinal service. Data included baseline characteristics, digital drawings, and outcomes. Retinal drawings were analysed in a masked fashion for site, size, and number of retinal breaks. Comparisons were made between the following groups and subgroups: pseudophakic eyes, phakic eyes, phakic eyes with cataract, and phakic eyes without cataract.
Of 500 eyes included, 146 were pseudophakic; 177 of the phakic eyes had cataract. The following were significant by univariate analysis: pseudophakic patients were older than phakic patients in general, but the same age as patients with cataract; in the pseudophakic group, there were lower proportions of females and of patients presenting with vitreous haemorrhage or with large or superotemporal breaks; higher proportions of pseudophakic eyes had small breaks and inferonasal breaks. Some differences remained significant when comparing pseudophakia eyes with cataract. Multivariate analysis comparing pseudophakia with phakia confirmed a lower chance in pseudophakia of large breaks, vitreous haemorrhage and superotemporal breaks, but higher chance of detached inferior breaks. Some variables were age dependent.
Differences were found between pseudophakic and phakic RRD patterns. These suggest special pathogenetic mechanisms in pseudophakic retinal detachment, which could help explain increased incidences of RRD after cataract surgery.
研究人工晶状体眼和白内障眼孔源性视网膜脱离(RRD)的发病模式是否存在差异。
回顾性分析我院玻璃体视网膜疾病专科就诊的年龄在 50 岁及以上的患者电子病历数据库。数据包括基本特征、视网膜裂孔的数字绘图和结局。视网膜绘图采用盲法分析裂孔位置、大小和数量。对以下各组和亚组进行比较:人工晶状体眼、白内障眼、白内障合并白内障、白内障不合并白内障。
500 只眼中,146 只为人工晶状体眼;177 只白内障眼中有 177 只患有白内障。单因素分析显示:一般来说,人工晶状体眼患者比白内障眼患者年龄大,但与白内障患者年龄相同;在人工晶状体眼中,女性和玻璃体出血或大或上方视网膜裂孔的患者比例较低;小裂孔和鼻下方视网膜裂孔的比例较高。当比较白内障合并白内障的人工晶状体眼时,一些差异仍然具有统计学意义。多变量分析比较了人工晶状体眼和白内障眼,证实了人工晶状体眼中大裂孔、玻璃体积血和上方视网膜裂孔的发生几率较低,但下方视网膜脱离的发生几率较高。一些变量与年龄有关。
人工晶状体眼和白内障眼 RRD 发病模式存在差异。这些差异提示人工晶状体眼视网膜脱离有特殊的发病机制,这有助于解释白内障手术后 RRD 发生率增加的原因。