Newcastle Eye Centre, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4PL, UK.
Biosciences Institute, Newcastle University, Catherine Cookson Building, Newcastle upon Tyne, NE2 4HH, UK.
Eye (Lond). 2023 Apr;37(6):1114-1122. doi: 10.1038/s41433-022-02061-y. Epub 2022 Apr 26.
To evaluate the influence of age on the clinical characteristics of primary rhegmatogenous retinal detachments (RRD).
We conducted a retrospective review of a prospectively collected dataset. Data regarding adult patients (aged 16-100 years) who had undergone primary RRD repair, were extracted from two online databases. Baseline demographics, preoperative clinical characteristics and surgical management details were collected. Age-based groups (16-30, 30-39, 40-49, 50-59, 60-69, 70-79, ≥80) were compared using univariate analysis, with multivariate testing for interaction of age with sex, laterality and pseudophakia.
In total, 8,133 eyes were analysed, of which the majority (59%) were in the 50-69 age-range peaking at 60, with a male predominance (64%). Myopia was significantly more frequent in patients aged <50 years. The presence of posterior vitreous detachment increased up to 50 years, then remained >95%. Foveal involvement, grade C proliferative vitreoretinopathy, total RD and greater RD extent were more common and progressively increased after 60 years, with worsening visual acuity. Isolated superior RRDs became more prevalent with age reaching a plateau in the age-range 50-69, before reducing again; conversely, isolated inferior RRDs were commoner in those <30, with a minimum in the 70-79 age-range. The incidence of fellow-eye RRD decreased linearly with age.
Age appeared a key variable in RRD phenotype influencing a wide range of RRD characteristics. The higher incidence of myopia, PVD absent and bilateral RRD in patients <40 years and the significant phenotypical differences in the under 40 and over 50 age-groups highlight that there are several discrete forms of RRD.
评估年龄对原发性孔源性视网膜脱离（RRD）临床特征的影响。
我们对一项前瞻性收集的数据进行了回顾性研究。从两个在线数据库中提取了接受原发性 RRD 修复的成年患者（年龄 16-100 岁）的数据。收集了基线人口统计学、术前临床特征和手术管理细节。使用单变量分析比较基于年龄的组（16-30、30-39、40-49、50-59、60-69、70-79、≥80），并对年龄与性别、侧别和假晶状体的相互作用进行多变量检验。
共分析了 8133 只眼，其中大多数（59%）年龄在 50-69 岁，60 岁时达到峰值，男性居多（64%）。<50 岁的患者中近视明显更为常见。后玻璃体脱离的存在在 50 岁前增加，然后保持>95%。黄斑受累、C 级增生性玻璃体视网膜病变、全层 RRD 和更大的 RRD 范围在 60 岁后更为常见，视力下降。孤立性上方 RRD 随着年龄的增长变得更为常见，在 50-69 岁年龄段达到高峰，然后再次减少；相反，<30 岁的患者中孤立性下方 RRD 更为常见，在 70-79 岁年龄段达到最低。对侧眼 RRD 的发生率随年龄呈线性下降。
年龄似乎是 RRD 表型的一个关键变量，影响广泛的 RRD 特征。<40 岁患者中近视、PVD 缺失和双眼 RRD 的发生率较高，<40 岁和>50 岁年龄组之间显著的表型差异突出了存在几种不同形式的 RRD。
