Threm Daniela, Nazirizadeh Yousef, Gerken Martina
Institute of Electrical and Information Engineering, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
J Biophotonics. 2012 Aug;5(8-9):601-16. doi: 10.1002/jbio.201200039. Epub 2012 Jun 8.
Photonic crystal technology has attracted large interest in the last years. The possibility to generate highly sensitive sensor elements with photonic crystal structures is very promising for medical or environmental applications. The low-cost fabrication on the mass scale is as advantageous as the compactness and reliability of photonic crystal biosensors. The possibility to integrate microfluidic channels together with photonic crystal structures allows for highly compact devices. This article reviews different types of photonic crystal sensors including 1D photonic crystal biosensors, biosensors with photonic crystal slabs, photonic crystal waveguide biosensors and biosensors with photonic crystal microcavities. Their applications in biomolecular and pathogen detection are highlighted. The sensitivities and the detection limits of the different biosensors are compared. The focus is on the possibilities to integrate photonic crystal biosensors on-chip.
近年来，光子晶体技术引起了广泛关注。利用光子晶体结构制造高灵敏度传感器元件的可能性在医学或环境应用方面非常有前景。大规模低成本制造与光子晶体生物传感器的紧凑性和可靠性同样具有优势。将微流体通道与光子晶体结构集成在一起的可能性使得设备高度紧凑。本文综述了不同类型的光子晶体传感器，包括一维光子晶体生物传感器、光子晶体平板生物传感器、光子晶体波导生物传感器和光子晶体微腔生物传感器。重点介绍了它们在生物分子和病原体检测中的应用。比较了不同生物传感器的灵敏度和检测限。重点关注将光子晶体生物传感器集成到芯片上的可能性。
