Howard Hughes Medical Institute, Cornell University, Ithaca, NY, USA.
Department of Physics - LASSP, Cornell University, Ithaca, NY, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 Jan;10(1). doi: 10.1002/wnan.1477. Epub 2017 Apr 24.
Optical trapping is a powerful and widely used laboratory technique in the biological and materials sciences that enables rapid manipulation and measurement at the nanometer scale. However, expanding the analytical throughput of this technique beyond the serial capabilities of established single-trap microscope-based optical tweezers remains a current goal in the field. In recent years, advances in nanotechnology have been leveraged to create innovative optical trapping methods that increase the number of available optical traps and permit parallel manipulation and measurement of arrays of optically trapped targets. In particular, nanophotonic trapping holds significant promise for integration with other lab-on-a-chip technologies to yield compact, robust analytical devices. In this review, we highlight progress in nanophotonic manipulation and measurement, as well as the potential for implementing these on-chip functionalities in biological research and biomedical applications. WIREs Nanomed Nanobiotechnol 2018, 10:e1477. doi: 10.1002/wnan.1477 This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.
光镊是生物学和材料科学中一种强大且应用广泛的实验室技术，可实现纳米尺度的快速操作和测量。然而，将该技术的分析通量扩展到基于单阱显微镜的传统光镊的串行能力之外，仍是该领域的当前目标。近年来，纳米技术的进步被用于开发创新的光镊方法，这些方法增加了可用光阱的数量，并允许对光阱捕获的目标阵列进行并行操作和测量。特别是，光子俘获技术有望与其他片上实验室技术集成，从而产生紧凑、稳健的分析设备。在这篇综述中，我们强调了光镊的纳米操控和测量方面的进展，以及在生物研究和生物医学应用中实现这些片上功能的潜力。
