Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
J Clin Endocrinol Metab. 2012 Aug;97(8):E1421-8. doi: 10.1210/jc.2012-1044. Epub 2012 Jun 7.
Several in vivo and in vitro studies suggest that sphingosine-1-phosphate (S1P) is known to act as a coupling factor, to stimulate osteoclastogenesis, to control the migration of osteoclast precursors between the blood and bone, and to stimulate the proliferation, migration, and survival of osteoblasts.
Using the determination of circulating S1P levels, we investigated which kinds of processes may be primarily affected by S1P in humans.
This was a cross-sectional study conducted in two clinical units in Korea.
Men (n = 86), premenopausal women (n = 94), and postmenopausal women (n = 357) participated in the study.
We measured S1P levels and their relationships with bone mineral density, biochemical bone turnover markers, and uncoupling indices.
S1P levels were significantly higher in the postmenopausal women than in the premenopausal women and men. High S1P concentrations were significantly associated with low bone mineral density values at some femur sites in the postmenopausal women (P = 0.015 to 0.049), at the lumbar spine in the premenopausal women (P = 0.017), and at all sites in men (P = 0.001 to 0.036) after adjustments with multiple covariates. S1P levels were positively correlated with bone resorption markers (P = 0.003 to 0.049), but not with formation markers in postmenopausal women. Higher S1P levels were associated with lower uncoupling indices (P = <0.001 to 0.048) in postmenopausal women.
These findings suggest that S1P may primarily affect bone resorption, resulting in bone loss.
几项体内和体外研究表明，1-磷酸鞘氨醇（S1P）已知作为偶联因子发挥作用，刺激破骨细胞生成，控制破骨细胞前体在血液和骨骼之间的迁移，并刺激成骨细胞的增殖、迁移和存活。
通过测定循环 S1P 水平，我们研究了 S1P 在人体内可能主要影响哪些过程。
这是一项在韩国两个临床单位进行的横断面研究。
男性（n=86）、绝经前女性（n=94）和绝经后女性（n=357）参加了这项研究。
我们测量了 S1P 水平及其与骨密度、生化骨转换标志物和去偶联指数的关系。
绝经后女性的 S1P 水平明显高于绝经前女性和男性。高 S1P 浓度与绝经后女性某些股骨部位（P=0.015 至 0.049）、绝经前女性腰椎（P=0.017）和所有男性部位（P=0.001 至 0.036）的骨密度值降低显著相关，这些部位的骨密度值在经过多种协变量调整后。S1P 水平与骨吸收标志物呈正相关（P=0.003 至 0.049），但与绝经后女性的形成标志物无关。较高的 S1P 水平与较低的去偶联指数相关（P=0.001 至 0.048）。
这些发现表明，S1P 可能主要影响骨吸收，导致骨质流失。
