Ganz Eva C, Griffin Craig E, Keys Deborah A, Flatgard Tami A
Animal Dermatology Clinic, Marina del Rey, CA, USA.
Vet Dermatol. 2012 Oct;23(5):387-e72. doi: 10.1111/j.1365-3164.2012.01058.x. Epub 2012 Jun 11.
Oral triamcinolone (T) and methylprednisolone (M) have been recommended at various dosages for the control of pruritus associated with feline allergic dermatitis.
The first objective was to determine effective dosages of methylprednisolone (Pfizer, New York, NY, USA) and triamcinolone (Boehringer Ingelheim Vetmedica, Inc., St Joseph, MO, USA) required to induce remission from pruritus associated with feline allergic dermatitis. The second objective was to compare efficacy of several different alternate day maintenance dosages. The third objective was to determine whether laboratory abnormalities occurred at effective dosages.
Thirty-two client-owned allergic cats were randomly assigned to the M or T groups.
Owners reported weekly on pruritus score and behavioural changes. Remission was defined as a pruritus score of ≤2/10, with 0 as the least and 10 as the most pruritic. Serum chemistry, complete blood count, fructosamine and urinalysis were assessed on day 0, at the end of the 7-14 day induction phase and at study completion.
Mean once daily doses required for induction were 1.41 mg/kg for M and 0.18 mg/kg for T. Mean alternate day maintenance doses were 0.54 mg/kg for M and 0.08 mg/kg for T. There was a statistically significant decrease in eosinophils and increase in fructosamine for both groups from baseline to study completion. Fructosamine levels did not exceed the reference range in any case.
These results suggest that triamcinolone is approximately seven times as potent as methylprednisolone, and that these dosages are efficacious and well tolerated for the control of pruritus in allergic cats.
口服曲安奈德（T）和甲泼尼龙（M）已被推荐使用不同剂量来控制与猫过敏性皮炎相关的瘙痒。
第一个目的是确定诱导与猫过敏性皮炎相关的瘙痒缓解所需的甲泼尼龙（辉瑞公司，美国纽约）和曲安奈德（勃林格殷格翰动物保健公司，美国密苏里州圣约瑟夫）的有效剂量。第二个目的是比较几种不同隔日维持剂量的疗效。第三个目的是确定在有效剂量下是否会出现实验室异常。
32只客户拥有的过敏性猫被随机分配到M组或T组。
主人每周报告瘙痒评分和行为变化。缓解定义为瘙痒评分为≤2/10，0为最不痒，10为最痒。在第0天、7 - 14天诱导期结束时和研究结束时评估血清化学、全血细胞计数、果糖胺和尿液分析。
诱导所需的平均每日剂量，M为1.41 mg/kg，T为0.18 mg/kg。平均隔日维持剂量，M为0.54 mg/kg，T为0.08 mg/kg。从基线到研究结束，两组的嗜酸性粒细胞均有统计学意义的下降，果糖胺均有升高。果糖胺水平在任何情况下均未超过参考范围。
这些结果表明，曲安奈德的效力约为甲泼尼龙的7倍，并且这些剂量对于控制过敏性猫的瘙痒是有效且耐受性良好的。
