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肝细胞癌和胃肠胰神经内分泌肿瘤:其他正电子发射断层扫描放射性示踪剂的潜在作用。

Hepatocellular carcinoma and gastroenteropancreatic neuroendocrine tumors: potential role of other positron emission tomography radiotracers.

机构信息

Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA 90033, USA.

出版信息

Semin Nucl Med. 2012 Jul;42(4):247-54. doi: 10.1053/j.semnuclmed.2012.02.001.

Abstract

18F-Fluorodeoxyglucose avidity for gastroenteropancreatic neuroendocrine tumors and hepatocellular carcinoma is variable, depending on the underlying tumor biology. Experience with non-fluorodeoxyglucose (FDG) tracers (eg, 18F-labeled amine precursors l-dihydroxyphenylalanine and 68Ga-DOTA-peptides for gastroenteropancreatic neuroendocrine tumors and radiolabeled acetate or choline for hepatocellular carcinoma) is evolving and expanding rapidly. This article reviews the role of FDG and non-FDG radiotracers in the imaging evaluation of patients with gastroenteropancreatic neuroendocrine tumors or hepatocellular carcinoma.

摘要

18F-氟代脱氧葡萄糖对胃肠胰神经内分泌肿瘤和肝细胞癌的亲和力因基础肿瘤生物学而异。非氟代脱氧葡萄糖(FDG)示踪剂(例如,用于胃肠胰神经内分泌肿瘤的 18F 标记的胺前体 l-二羟基苯丙氨酸和 68Ga-DOTA-肽,以及用于肝细胞癌的放射性标记的乙酸盐或胆碱)的应用经验正在迅速发展和扩大。本文回顾了 FDG 和非 FDG 放射性示踪剂在胃肠胰神经内分泌肿瘤或肝细胞癌患者影像评估中的作用。

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