Department of Mycology, General Hospital of Mexico, Dr. Balmis 148, Colonia Doctores, Mexico City, Mexico.
Clin Dermatol. 2012 Jul-Aug;30(4):413-9. doi: 10.1016/j.clindermatol.2011.09.013.
Cutaneous zygomycosis is a fungal infection caused by zygomycetes that affects the skin. It occurs in uncontrolled diabetic patients and immunosuppressed individuals. It has 2 clinical forms: primary cutaneous zygomycosis and secondary cutaneous zygomycosis. The first is characterized by necrotic lesions and the fungus is usually inoculated by trauma. If diagnosed early, it generally has a good prognosis. Secondary zygomycosis is usually a complication and extension of the rhinocerebral variety that starts as a palpebral fistula and progresses to a necrotic lesion with a poor prognosis. The diagnosis is made by identification of the fungus by direct KOH examination, culture, and biopsy. Treatment for the primary disease is surgical debridement plus amphotericin B. The secondary type is treated with amphotericin B and/or posaconazole.
皮肤接合菌病是一种由接合菌引起的真菌感染，影响皮肤。它发生在未控制的糖尿病患者和免疫抑制个体中。它有 2 种临床形式：原发性皮肤接合菌病和继发性皮肤接合菌病。第一种表现为坏死性病变，真菌通常通过创伤接种。如果早期诊断，一般预后良好。继发性接合菌病通常是鼻脑型的并发症和延伸，从眼睑瘘管开始，进展为坏死性病变，预后不良。诊断通过直接 KOH 检查、培养和活检来识别真菌。原发性疾病的治疗是手术清创加两性霉素 B。继发性类型用两性霉素 B 和/或泊沙康唑治疗。
