Departments of Pathology and Laboratory Medicine and Molecular and Medical Pharmacology, The David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.
Cell Metab. 2012 Jun 6;15(6):789-90. doi: 10.1016/j.cmet.2012.05.004.
Cancer cells in culture obtain ATP and biosynthetic precursors primarily by aerobic glycolysis, not by mitochondrial glucose oxidation. In this issue of Cell Metabolism, Marin-Valencia et al. (2012) demonstrate that glioblastoma, an aggressive and, in culture, highly glycolytic cancer, primarily uses glucose oxidation to meet energetic and biosynthetic demands in vivo.
在培养的癌细胞中，细胞主要通过有氧糖酵解而非线粒体葡萄糖氧化获取三磷酸腺苷（ATP）和生物合成前体。在本期《细胞代谢》中，Marin-Valencia 等人（2012）证明，神经胶质瘤（一种侵袭性的、在培养中高度糖酵解的癌症）在体内主要利用葡萄糖氧化来满足能量和生物合成需求。
