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生活事件和应激对老年男性中性粒细胞功能的影响。

Effects of life events and stress on neutrophil functions in elderly men.

机构信息

Nihon Medi-Phisics, Co,, Ltd,, Tokyo, 3-4-10 Shinsuna, Koto-ku, Tokyo, 136-0075, Japan.

出版信息

Immun Ageing. 2012 Jun 9;9(1):13. doi: 10.1186/1742-4933-9-13.

DOI:10.1186/1742-4933-9-13
PMID:22682371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3411432/
Abstract

BACKGROUND

Psychological stress or life events might significantly decrease neutrophil function in elderly individuals and lead to infectious diseases. However, relationships between these factors have not been examined in detail.We investigated the relationships between neutrophil function measured using the nitroblue tetrazolium (NBT) reduction test and measurements of psychological stress and life events among 81 men aged over 60 years.

RESULTS

The numbers and scores for life events were significantly higher (p < 0.01, respectively) in a group with values reflecting phagocytosis below the median than in a control group.

CONCLUSIONS

Chronic psychological stress due to life events decreases neutrophil functions among elderly men.

摘要

背景

心理压力或生活事件可能会显著降低老年人的中性粒细胞功能，导致感染性疾病。然而，这些因素之间的关系尚未得到详细研究。我们调查了 81 名年龄在 60 岁以上的男性中使用硝基四氮唑蓝（NBT）还原试验测量的中性粒细胞功能与心理压力和生活事件测量之间的关系。

结果

反映吞噬作用低于中位数的组的生活事件数量和评分明显更高（分别为 p < 0.01）。

结论

生活事件导致的慢性心理压力会降低老年男性的中性粒细胞功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88ff/3411432/18fce0369677/1742-4933-9-13-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88ff/3411432/18fce0369677/1742-4933-9-13-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88ff/3411432/18fce0369677/1742-4933-9-13-1.jpg

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