Sandhu T
Avian Dis. 1979 Jul-Sep;23(3):662-9.
Since Pasteurella anatipestifer (PA) serotypes 1, 2, and 5 gave no significant protection against heterologous serotype challenge, a trivalent formalin-inactivated bacterin containing all these serotype cells was developed and tested in the laboratory. Two inoculations of bacterin in White Pekin ducklings at 10 and 17 days of age gave highly significant protection against challenge with virulent organisms. The protection lasted only 2 weeks after the second inoculation. A third bacterin inoculation given at 31 days or exposure to an active field infection during the period of protection extended protection to market age (7 wk). Aluminum-hydroxide-gel-adsorbed bacterin gave no better protection than bacterin without adjuvant. One inoculation of multiple oil-emulsion (MOE) bacterin gave absolute protection up to market age: unfortunately, it produced noticeable tissue reactions at the site of inoculation. Day-old ducklings were also responsive to PA bacterin, and developed significant immunity against experimental challenge.
由于鸭疫里默氏杆菌（PA）1型、2型和5型血清型对异源血清型攻击没有显著的保护作用，因此研制了一种含有所有这些血清型细胞的三价福尔马林灭活菌苗，并在实验室进行了测试。对白来航雏鸭在10日龄和17日龄时进行两次菌苗接种，对强毒菌攻击提供了高度显著的保护。这种保护在第二次接种后仅持续2周。在31日龄进行第三次菌苗接种或在保护期内接触活跃的田间感染，可将保护期延长至上市日龄（7周）。氢氧化铝凝胶吸附菌苗的保护效果并不比无佐剂菌苗更好。接种一次多油乳剂（MOE）菌苗可提供直至上市日龄的绝对保护：不幸的是，它在接种部位产生了明显的组织反应。一日龄雏鸭对PA菌苗也有反应，并对实验性攻击产生了显著免疫力。
