有证据表明，由于脂质在乳腺中持续积累，使用曲拉通WR1339会低估三酰甘油进入泌乳大鼠血浆的速率。
Evidence that use of Triton WR1339 underestimates the triacylglycerol entry rate into the plasma of lactating rats owing to continued accumulation of lipid in the mammary gland.
作者信息
Tedstone A E, Ilic V, Williamson D H
机构信息
Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, U.K.
出版信息
Biochem J. 1990 Dec 15;272(3):835-8. doi: 10.1042/bj2720835.
Abstract
Measurement of the entry rate of an intragastric load of [14C]triolein into the plasma in the presence of Triton WR1339 gave similar values for virgin and weaned rats, but significantly lower values for lactating rats. This decreased entry rate (65%) in lactating compared with virgin rats was due to a failure of Triton WR1339 to inhibit the accumulation of [14C]lipid in the mammary gland. This is further evidence that mammary-gland lipoprotein lipase behaves differently from that in white adipose tissue or muscle.
摘要
在存在曲拉通WR1339的情况下，测量胃内负荷的[14C]甘油三酯进入血浆的速率，未断奶大鼠和刚断奶大鼠得到的数值相似，但哺乳期大鼠的数值显著更低。与未断奶大鼠相比，哺乳期大鼠的这种进入速率降低（65%）是由于曲拉通WR1339未能抑制[14C]脂质在乳腺中的蓄积。这进一步证明乳腺脂蛋白脂肪酶的行为与白色脂肪组织或肌肉中的不同。
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本文引用的文献
1
THE CLEARING FACTOR LIPASE AND ITS ACTION IN THE TRANSPORT OF FATTY ACIDS BETWEEN THE BLOOD AND TISSUES.清除因子脂肪酶及其在血液与组织间脂肪酸转运中的作用。
Adv Lipid Res. 1963;1:133-82. doi: 10.1016/b978-1-4831-9937-5.50010-7.
2
Hypertrophic and hyperplastic changes in the alimentary canal of the lactating rat.哺乳期大鼠消化道的肥大和增生性变化。
J Pathol Bacteriol. 1963 Jan;85:179-88. doi: 10.1002/path.1700850117.
3
The mechanism responsible for the hypercholesteremia induced by triton WR-1339.由曲拉通WR - 1339诱导的高胆固醇血症的发病机制。
J Exp Med. 1953 Jan;97(1):117-30. doi: 10.1084/jem.97.1.117.
4
Effect of hydrophobic surfactant (Pluronic L-81) on lymphatic lipid transport in the rat.疏水性表面活性剂（普朗尼克L-81）对大鼠淋巴脂质转运的影响。
Am J Physiol. 1980 Nov;239(5):G348-53. doi: 10.1152/ajpgi.1980.239.5.G348.
5
Regulation of hepatic fatty acid metabolism. The activities of mitochondrial and microsomal acyl-CoA:sn-glycerol 3-phosphate O-acyltransferase and the concentrations of malonyl-CoA, non-esterified and esterified carnitine, glycerol 3-phosphate, ketone bodies and long-chain acyl-CoA esters in livers of fed or starved pregnant, lactating and weaned rats.肝脏脂肪酸代谢的调节。喂食或饥饿的怀孕、哺乳和断奶大鼠肝脏中线粒体和微粒体酰基辅酶A：sn-甘油3-磷酸O-酰基转移酶的活性以及丙二酰辅酶A、非酯化和酯化肉碱、甘油3-磷酸、酮体和长链酰基辅酶A酯的浓度。
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6
Rates of triacylglycerol entry into the circulation in the lactating rat.泌乳大鼠中三酰甘油进入循环系统的速率。
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8
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10
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J Physiol. 1967 May;190(2):321-32. doi: 10.1113/jphysiol.1967.sp008211.
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