Department of Public Health Sciences, 2-040 Li Ka Shing Center for Health Research and Innovation, University of Alberta, Edmonton, AB, T6G 2E1, Canada.
Qual Life Res. 2013 May;22(4):791-9. doi: 10.1007/s11136-012-0214-7. Epub 2012 Jun 9.
We assessed the associations between multimorbidity and health-related quality of life (HRQL), and healthcare utilization, based on 16 common self-reported chronic conditions.
A cross-sectional questionnaire survey including the EQ-5D was conducted in a sample of the general population of adults (≥18 years) living in Alberta, Canada. Multiple linear and logistic regressions were used to assess the association between multiple chronic conditions and HRQL, hospitalization and emergency department (ED) use.
A total of 4,946 respondents reported their HRQL, noting problems mostly with pain or discomfort (48.0%). All chronic conditions were associated with a clinically important reduction in HRQL, the highest burden with anxiety or depression (-0.19, 95% CI -0.21, -0.16) and chronic pain (-0.19, 95% CI -0.21, -0.17). Multimorbidity was associated with a clinically important reduction in the EQ-5D index score (-0.12, 95% CI -0.14, -0.11) and twice the likelihood of being hospitalized (OR = 2.2, 95% CI 1.7, 2.9) or having an ED visit (OR = 1.8, 95% CI 1.4, 2.2).
Pain or discomfort is a common problem in people living with chronic conditions, and the existence of multimorbidity in these individuals is associated with a reduction in the HRQL as well as frequent hospitalization and emergency department visits.
我们评估了 16 种常见的自我报告的慢性疾病基础上的多种疾病与健康相关的生活质量（HRQL）和医疗保健利用之间的关联。
在加拿大阿尔伯塔省的成年人（≥18 岁）的一般人群样本中进行了一项包含 EQ-5D 的横断面问卷调查。使用多元线性和逻辑回归来评估多种慢性疾病与 HRQL、住院和急诊部（ED）使用之间的关系。
共有 4946 名受访者报告了他们的 HRQL，指出大多数存在疼痛或不适（48.0%）。所有慢性疾病都与 HRQL 的临床显著下降相关，其中焦虑或抑郁（-0.19，95%CI-0.21，-0.16）和慢性疼痛（-0.19，95%CI-0.21，-0.17）的负担最高。多种疾病与 EQ-5D 指数评分的临床显著下降相关（-0.12，95%CI-0.14，-0.11），并且住院（OR=2.2，95%CI1.7，2.9）或急诊就诊（OR=1.8，95%CI1.4，2.2）的可能性增加一倍。
疼痛或不适是患有慢性疾病的人常见的问题，而这些患者的多种疾病的存在与 HRQL 下降以及频繁住院和急诊就诊有关。
